The home side come into proceedings off the back of four straight defeats in all competitions, while visitors Kilmarnock make the trip following a loss against Livingston.
Match preview
Dundee United have struggled to generate momentum this season and sit bottom of the Scottish Premiership on nine points under Liam Fox.
The Terrors are in dire need of a result to avoid being cut adrift at the bottom of the table and have lost their last four fixtures across all competitions.
Frustratingly, Dundee United came extremely close to getting a commendable point away to Celtic in their last match, though were denied dramatically in a 4-2 defeat.
Goals from Steven Fletcher and Dylan Levitt had cancelled out a Sead Haksabanovic double to leave the score level at 2-2 going into stoppage time, before last-gasp strikes from Kyogo Furuhashi and Liel Abada secured the victory for the hosts.
Fox will be keen for his side to take the positives from the Celtic match as they look to get their season back on track this Wednesday.
Kilmarnock make the trip to Tannadice occupying 10th place in the table and they will be aiming to elevate themselves further away from the relegation zone with a victory.
Derek McInnes has seen his side make progress in the last couple of months, though they have lost their last two Premiership games and have a point to prove against Dundee United.
On the road, they have gained just a single point from a possible 21 available, which came against St Mirren in a 0-0 stalemate last month.
Last time out, Kilmarnock suffered a damaging 3-2 defeat to Livingston at Rugby Park as efforts from Bruce Anderson, Sean Kelly and an own goal by Chris Stokes meant a brace from Joe Wright was in vain for the Ayrshire side.
Kilmarnock will need to be better away from home this midweek if they are to take a result from basement battlers Dundee United.
Dundee United Scottish Premiership form:
W
W
D
L
L
L
Dundee United form (all competitions):
W
D
L
L
L
L
Kilmarnock Scottish Premiership form:
W
D
D
W
L
L
Kilmarnock form (all competitions):
D
D
W
W
L
L
Team News
Dundee United will be without defender Charlie Mulgrew for the match against Kilmarnock due to the veteran sustaining a recent thigh injury.
Tony Watt and Dylan Levitt may return from the start following their positive impact from the bench against Celtic last weekend.
Kyle Lafferty is still serving a ban for the visitors and will not be available for the trip to Tannadice, while fellow striker Scott Robinson is absent as he recovers from a long-term injury.
Calum Waters and Ben Chrisene are unavailable for the tie due to respective knocks. Ash Taylor and Liam Donnelly are at risk of suspension if they pick up a booking during the match.
Dundee United possible starting lineup:
Birighitti; Smith, Edwards, McMann; Freeman, Djoum, Levitt, Harkes, Behich; Fletcher, Watt
Kilmarnock possible starting lineup:
Hemming; Alebiosu, Taylor, Wright, Stokes; Donnelly, Power; McKenzie, Armstrong, Jones; Cameron
We say: Dundee United 1-1 Kilmarnock
In a match that has significant consequences at the foot of the table, both sides will look to overpower each other to climb further away from the relegation places.