The visitors, meanwhile, will be desperate to return to winning ways after losing their last six matches.
Match preview
After winning promotion to the fifth tier for the first time in their history last term, Dorking are currently in a battle to retain their place in the National League.
Dorking bounced back from consecutive defeats to claim beat Maidenhead United 3-1 on Saturday thanks to Jason Prior brace and a Josh Taylor strike.
As a result of the victory, Dorking moved up one place to 19th position, leaving them three points above the relegation zone.
After extending their unbeaten home run to four games at the weekend, Marc White's side will be looking forward to another game at Meadowpark on Tuesday.
Having picked up 31 of their 40 points from home matches, Dorking's final four home matches could prove pivotal in their bid to remain in the National League.
While the hosts will be buoyed by Saturday's victory, Southend will have to pick themselves up from a sixth consecutive defeat.
Their weekend away meeting with Altrincham was goalless until Nathan Ralph was penalised for a foul in the box, presenting Regan Linney with the chance to score from the spot, condemning the Shrimps to a narrow 1-0 defeat.
With nine points separating them from the top seven, Southend are set to remain in the fifth tier for a third consecutive season.
If Southend are to pick up points between now and the end of the campaign then they will need to improve in the final third, after failing to score in four of their last six matches.
The Shrimps can draw inspiration from the fact that they have won both of their competitive meetings with Dorking, including a 2-0 victory when the two sides met in November.
Dorking Wanderers National League form:
L
D
W
L
L
W
Southend United National League form:
L
L
L
L
L
L
Team News
Dorking are expected to be without the services of Matt Briggs, Nicky Wheeler, Niall McManus and Alfie Egan due to injury issues.
Aaron Kuhl made his competitive debut as a substitute on Saturday, but he may have to settle for a place on the bench once again, with White set to name an unchanged lineup.
As for the visitors, Noor Husin has been ruled out of the last two games with an ankle, and he is expected to remain unavailable for Tuesday's contest.
Jake Hyde returned from a spell on the sidelines to feature as a late substitute against Altrincham, and he may have to be content with a role off the bench on Tuesday, as Southend manage his comeback from injury.
Dorking Wanderers possible starting lineup:
Lincoln; Francomb, Craig, Cook; Muitt, Gallagher, Moore, Taylor, Bowerman; McShane, Prior
Southend United possible starting lineup:
Arnold; Scott-Morriss, Hobson, Kensdale, Ralph; Mooney, Miley, Fonguck, Bridge; Murphy, Cardwell