The Addicks, meanwhile, will be looking to end their 16-game winless league run as they fight to retain their third-tier status.
Match preview
Derby's bid to finish in the top two suffered a setback in Saturday's away clash with fellow promotion hopefuls Barnsley.
The Rams took the lead through Sonny Bradley in the 18th minute, but they were ultimately left empty-handed following a brace from Barnsley midfielder Adam Phillips.
Fortunately for Paul Warne's side, third-placed Bolton Wanderers also fell to defeat at the weekend, ensuring they kept hold of second position due to their goal-difference advantage.
After experiencing a disappointing trip to Oakwell, Derby will be looking forward to returning to Pride Park, where they have won three of their last four home matches (D1).
The Rams have already enjoyed success against Charlton this month, with Nathaniel Mendez-Laing netting the only goal in a 1-0 victory at The Valley on February 3.
Charlton boss Nathan Jones has overseen three consecutive draws since beginning his tenure with a narrow defeat to Reading.
The Addicks were involved in score draws against Lincoln City and Bolton Wanderers, before they played out a goalless affair with leaders Portsmouth on Saturday.
Although Charlton would have been content with taking a point off the table toppers, the Addicks are now winless in 16 league matches since beating Cheltenham Town at the end of November.
As a result of their long wait for a win, Charlton are currently languishing in 20th place and just one point above the bottom four.
Having failed to win any of their last 11 head-to-head away matches, the Addicks are looking to claim an away victory over Derby since winning 2-0 in February 1999.
Derby County League One form:
W
W
D
W
W
L
Charlton Athletic League One form:
D
L
L
D
D
D
Team News
Derby are expected to be without the services of Jake Rooney, Craig Forsyth, Tyreece John-Jules, Conor Washington and James Collins due to injury.
Martyn Waghorn and Corey Blackett-Taylor are both doubts, with the pair set to be assessed ahead of Tuesday's encounter.
Tom Barkuizen could be recalled to the starting lineup after dropping down to the bench for Saturday's defeat to Barnsley.
As for the visitors, they are still unable to call upon Kayne Ramsay and Miles Leaburn, who are both sidelined with hamstring problems.
Defender Macaulay Gillesphey could replace Lloyd Jones, who is set to serve a two-match suspension after picking up his 10th yellow card of the League One season.
Chuks Aneke could be presented with a starting place, having made three consecutive substitute appearances since returning from injury.
Derby County possible starting lineup:
Wildsmith; Nelson, Bradley, Cashin; Wilson, Adams, Bird, Elder; Barkhuizen, Sibley, Mendez-Laing
Charlton Athletic possible starting lineup:
Isted; Edmonds-Green, Gillesphey, Thomas; Watson, Bakinson, Dobson, Anderson, Small; Aneke, Kanu