The Eagles succumbed to a Tottenham Hotspur fightback in a 3-1 loss to the Lilywhites in gameweek 27, before the Hatters suffered an excruciating 3-2 defeat to Aston Villa.
Match preview
Truly defining the expression back with a bang, Palace jewel Eberechi Eze - making his first Premier League start since the end of January due to a muscular injury - broke the deadlock at the Tottenham Hotspur Stadium with a ferocious free kick just before the hour mark.
Oliver Glasner's men entered the final 15 minutes on course for a second win in the Austrian's second match in charge, but a late Tottenham flurry saw Timo Werner, Cristian Romero and Son Heung-min turn the match around to send the Eagles back to Selhurst Park empty-handed.
Glasner's Palace were given a taste of their own medicine in North London, having overcome Burnley in their first game under new management thanks to three quickfire strikes, and the Eagles remain in danger of being dragged deeper into the demotion dogfight in 14th place in the Premier League table.
Form at Selhurst Park since the festive period has provided a sliver of comfort for the Eagles faithful, though, as only one of Palace's last six games on home turf has seen the hosts fall short - their 3-1 loss to Chelsea last month - and Eze's imminent return to Selhurst Park soil will also put a few more smiles on faces.
Furthermore, four of Palace's last five Premier League fixtures against newly-promoted sides have seen the Eagles triumph - the most recent being their 3-0 success over Burnley in Glasner's inaugural match - but the one outlier in that sequence came against none other than Saturday's visitors.
Four days on from witnessing Erling Haaland's five-goal masterclass in their FA Cup loss to Manchester City, pained Luton Town fans watched another red-hot centre-forward terrorise their backline on March 2, as Aston Villa's Ollie Watkins put the Lions two goals to the good inside the opening 45 minutes.
However, after threatening an improbable turnaround against Man City, Rob Edwards's men looked to have stolen a point from the jaws of defeat courtesy of Tahith Chong and Carlton Morris's efforts, only for Lucas Digne to nod home Villa's winning goal at the back stick with 89 minutes on the clock.
Luton are no strangers to conceding last-minute headers at home - see Declan Rice for Arsenal in December - and another agonising aerial effort means that it is now five losses on the bounce for the leaky Hatters in all tournaments, four of which have come in the top flight.
Eighteenth place in the table belongs to Edwards's side ahead of the weekend - a standing which they are guaranteed to finish the gameweek in as they sit four points adrift of Nottingham Forest - although they still have a game in hand over their fellow relegation battlers.
Severely impacted by their growing injury list, Luton have shipped multiple goals in each of their last six matches - conceding an alarming 22 in total over that stretch - but they ran out 2-1 winners over Crystal Palace at Kenilworth Road in November and could now complete a league double against the Eagles for just the fourth time.
Crystal Palace Premier League form:
W
L
L
D
W
L
Luton Town Premier League form:
W
D
L
L
L
L
Luton Town form (all competitions):
D
L
L
L
L
L
Team News
While Eze returned from his month-long absence for Palace's encounter with Tottenham, Glasner could not call upon Michael Olise (thigh), Rob Holding (ankle), Cheick Doucoure (Achilles), Jesurun Rak-Sakyi (thigh) or Marc Guehi, the latter of whom has now undergone surgery on a knee injury.
Jordan Ayew - the second-most fouled player in the Premier League this season behind Newcastle United's Bruno Guimaraes - was taken off in the 71st minute of the loss to Spurs with a hip problem, but Glasner does not think that the attacker had sustained anything severe.
Either Matheus Franca or Odsonne Edouard will deputise for Ayew if need be, but after a strong first 75 minutes in North London, Glasner should otherwise see no need to alter his 3-4-2-1 system.
Meanwhile, Luton boss Edwards's decision to risk Amari'i Bell for the Villa encounter backfired horribly, as after the defender was taken off early in the FA Cup loss to Man City, he lasted just six minutes last weekend before succumbing to a thigh injury.
Bell is one of a staggering 10 concerns for the ravaged Hatters, who cannot call upon Mads Andersen (calf), Albert Sambi Lokonga (thigh), Jacob Brown (knee), Elijah Adebayo (thigh), Dan Potts (thigh), Tom Lockyer (heart) or Marvelous Nakamba (knee) for the trip to Selhurst Park either.
Two potential replacements for Bell - Joe Johnson and Gabriel Osho - were also unavailable for the visit of the Lions, so either Daiki Hashioka or Pelly Ruddock Mpanzu might have to be shoe-horned into a central role this weekend.
Crystal Palace possible starting lineup:
Johnstone; Ward, Andersen, Richards; Munoz, Wharton, Lerma, Mitchell; Eze, Ayew; Mateta
Luton Town possible starting lineup:
Kaminski; Hashioka, Mengi, Burke; Kabore, Barkley, Clark, Doughty; Ogbene, Chong; Morris
We say: Crystal Palace 3-1 Luton Town
A threadbare Luton deserve plaudits for the manner of their fightback against Champions League-chasing Aston Villa, and no matter who Edwards's men are faced with, the Hatters always have a goal in them and have now scored 10 successive fixtures.