One of only two unbeaten sides heading into this week's ninth round, Luciano Spalletti's men followed up victory over Torino with a 6-1 crushing of Ajax in Amsterdam, while their hosts have picked up just three points since achieving promotion.
Match preview
Taking their scintillating start to the 2022-23 season to even greater heights, Napoli came from behind on Tuesday to destroy Ajax in the Champions League and record a ninth win from 11 matches this term.
After Giacomo Raspadori headed in the Partenopei's equaliser at Johan Cruijff ArenA, they found themselves 3-1 ahead at the break, before Raspadori notched his second and laid on a Khvicha Kvaratskhelia strike in the second half.
Giovanni Simeone netted a sixth late on, as Napoli swept clear at the top of Group A; making light of Spalletti's summertime overhaul following the departure of several senior players. Indeed, rejuvenated by some new blood, new-look Napoli are now even better.
In Europe, they have scored 13 times already and sit three points above Liverpool, while back on the Italian peninsula they are a similarly frightening prospect: only Fiorentina and Lecce have prevented them from winning so far.
Curiously, though, the Campanian club have failed to win three of their last six meetings with promoted sides - August's draw versus Lecce in August and two defeats to Empoli last term - so may possess an Achilles' heel in that regard.
Nonetheless, Napoli have attempted the most shots in Serie A this season (150), while no side have faced more than Cremonese so far (138); indicating the likely nature of a lopsided match-up in Lombardy.
After kicking off their long-awaited return to the elite level with four defeats in a row, Cremonese have drawn three of their last four league matches.
However, for only the second time they have failed to win any of their first eight Serie A matches, following a 1-1 draw with another promoted side, Lecce.
Hopes of a first top-flight success for 26 years were raised when Daniel Ciofani became the club's oldest scorer in Serie A - putting Cremonese ahead from the penalty spot - but their relegation rivals struck back with a spot-kick of their own just before the interval.
Coach Massimiliano Alvini had been cursed with a relatively tough run of fixtures to start Cremo's comeback campaign, but a chance spurned last week sees them in further danger of being cut adrift within the drop zone.
Now set to face a side that has already scored 18 times in the league this season, the Grigiorossi have only found the net twice themselves in their last four games - surely not a recipe for success on Sunday.
Cremonese Serie A form:
L
L
D
D
L
D
Napoli Serie A form:
D
D
W
W
W
W
Napoli form (all competitions):
W
W
W
W
W
W
Team News
Already spoiled for choice in terms of in-form attackers, Luciano Spalletti will see his options bolstered by the early return of Victor Osimhen from injury this weekend.
The Nigeria international has rejoined some elements of training and will be available should Spalletti need to summon him from the bench; Piotr Zielinski is also fit to participate after picking up a knock against Ajax.
With Osimhen feeling his way back into first-team action, Giacomo Raspadori and Giovanni Simeone go head-to-head for one place up front in Cremona, and they should be supported by Khvicha Kvaratskhelia.
The Georgian winger has scored five league goals so far, and the only player to have managed more at this stage of his debut Serie A season for Napoli since the 1990s was Edinson Cavani, back in 2010.
Cremonese defender Luka Lochoshvili will attempt to keep his international teammate at bay, and could be partnered by Jack Hendry in the back four, as Vlad Chiriches remains sidelined by injury.
While Daniel Ciofani will hope to keep his place as the hosts' central striker, both Cyriel Dessers and young Felix Afena-Gyan are applying pressure to the 37-year-old frontman, who has spent most of his career in Calcio's lower leagues.
Cremonese possible starting lineup:
Radu; Sernicola, Hendry, Lochoshvili, Valeri; Castagnetti, Ascacibar; Okereke, Pickel, Zanimacchia; Dessers
Napoli possible starting lineup:
Meret; Di Lorenzo, Kim, Ostigard, Rui; Anguissa, Lobotka, Ndombele; Politano, Simeone, Kvaratskhelia