Both teams head into this one off the back of respective defeats last time out and will be keen to bounce back by securing all three points here.
Match preview
Club America got their season off to an agonising start as they were on the receiving end of a 2-1 defeat against Juarez when the teams went toe to toe on July 1.
Andre Jardine's men broke the deadlock in 15th minute through Leonardo Suarez and looked set to come out on top head into the final knockings of the game in which Aitor Garcia and Angel Zapata netted to complete a dramatic turnaround.
Consequently, Los Azulcremas sit bottom but one in the Liga MX table, albeit with a game in hand after their clash against Queretaro originally scheduled for Monday was postponed.
Next up is the challenge of an opposing outfit who are without a victory in the last 14 editions of this fixture across all competitions, losing 11 of them.
Off the back of three straight home defeats leading up to Sunday's clash, the hosts set out to turn things around in front of their fans.
Puebla were a tad unfortunate to come away empty-handed from a 3-2 thriller against Santos Laguna in Saturday's meeting at Estadio Cuauhtemoc.
Goals from Federico Mancuello and Brayan Angulo saw Eduardo Arce's men lead 1-0 and 2-1 but they failed to hold on to their advantage on either occasion before Juan Brunetta grabbed the winner 12 minutes from time.
With one point picked up from their opening two games, Los Camoteros sit 13th in the standings, two points adrift of a place in the top half.
Winless in each of their last four away matches, Sunday's visitors have it all to do this weekend in what is set to be another tough outing on the road.
Club America Liga MX form:
W
W
L
W
L
L
Puebla Liga MX form:
D
L
W
L
D
L
Team News
Thirty-year-old Jonathan Rodriguez is unavailable for Club America due to a knee injury which he picked up towards the back end of last season.
Alejandro Zendejas is currently on international duty with the United States at the ongoing Gold Cup and he will not be playing any part for the hosts here.
Puebla's Brayan Angulo has started the season in good goalscoring for having netted in both of his opening two matches, making him one to keep an eye on.
Martin Barragan will be pushing for a return to the visitors' starting lineup after shaking off an injury scare to feature against Santos last time out.
Club America possible starting lineup:
Jimenez; Alvarez, Araujo, Caceres, Layun; Sanchez, Dos Santos; Suarez, Valdes, Rodriguez; Martinez
Puebla possible starting lineup:
Rodriguez; Garcia, De Buen, Silva, Angulo, Velasco; Baltazar, Gonzalez, Mancuello; Martinez, Robles