The visitors, who currently occupy 18th place, will be desperate to end their poor run of form, having failed to win any of their last 11 league matches.
Match preview
Charlton's caretaker boss Curtis Fleming is preparing to take charge of his second game since Michael Appleton was relieved of his duties earlier this month.
Fleming began his interim tenure with a 1-1 draw in last Saturday's away meeting with Blackpool, bringing an end to a run of three consecutive league defeats.
Blackpool's Karamoko Dembele opened the scoring in the 53rd minute, before a Marvin Ekpiteta own goal ensured Charlton returned home with a point to their name.
With Charlton sitting just four points above the drop zone, they will be desperate to claim their first league win since November in Saturday's home clash with Derby.
While they may be experiencing a poor run of form, the Addicks can take confidence from the fact they have won their last two home games against Derby.
After taking a point from two away matches, Derby returned to winning ways in their recent home outing against Cheltenham Town.
The Rams fell behind in the 50th minute, but they turned the game in their favour thanks to goals from Max Bird and James Collins.
Having won 17, drawn five and lost seven of their 29 league matches, Derby currently sit in fourth position with just one point separating them from second-placed Bolton Wanderers.
Despite taking just one point from their last two away matches, Paul Warne's side currently hold the second-best away record in the division having won nine, drawn two and lost four of their 15 away league games this season.
If they can claim their 10th away victory in Saturday's contest, it would represent their first win at The Valley since beating Charlton 1-0 in the Championship in April 2016.
Charlton Athletic League One form:
L
D
L
L
L
D
Derby County League One form:
L
W
W
D
L
W
Derby County form (all competitions):
W
L
W
D
L
W
Team News
Charlton are still upon to call upon Michael Hector, Chuks Aneke and Miles Leaburn due to hamstring injuries, while Terry Taylor, Conor McGrandles and Panutche Camara are not expected to return in time for Saturday's contest.
Macaulay Gillesphey was forced off with a hamstring issue at half time against Blackpool, making him a fitness doubt for Saturday's contest.
Wing-back Tayo Edun is available for selection after he missed last weekend's trip to Bloomfield Road through suspension.
As for the Rams, they are expected to be without the services of Jake Rooney, Craig Forsyth, Korey Smith, Martyn Waghorn, Conor Washington and Tyreece John-Jules.
Callum Elder is also a doubt for Saturday's away trip after he missed the win over with a hamstring problem.
Corey Blackett-Taylor was presented with his first Derby start last weekend following his arrival from Charlton earlier this month, and the winger is expected to retain his place for the fixture against his former side.
The Gambia international Ebou Adams is expected to be among the substitutes after joining on loan from Cardiff City for the rest of the season.
Charlton Athletic possible starting lineup:
Maynard-Brewer; Ness, Jones, Thomas; T. Watson, Edmonds-Green, Dobson, Bakinson, Edun; May, Ladapo
Derby County possible starting lineup:
Vickers; Wilson, Nelson, Cashin, Sibley; Barkhuizen, Bird, Hourihane, Blackett-Taylor; Mendez-Laing; Collins