The teams come into this one in highly contrasting forms as the home side look to avoid a fifth straight defeat, while the visitors have won all but one of their seven league encounters this term.
Match preview
PSV Eindhoven showed great resolve to come out on top in a thrilling 4-3 contest against Feyenoord at the Philips Stadion two Sundays ago.
Goals from Jarrad Branthwaite and Cody Gakpo sandwiched in between strikes from Oussama Idrissi and Danilo saw a breathtaking first half end 2-2, before Guus Til and Armando Obispo scored in the second half to get the job done for Ruud van Nistelrooy's men despite Orkun Kokcu's effort.
Consequently, the Rood-witten have reclaimed leadership of the league table from defending champions Ajax, albeit only on goal difference.
Next up is the challenge of an opposing outfit who have been beaten in each of the most recent eight editions of this fixture dating back to 2014.
Currently averaging four goals per game from their three domestic outings on the road so far, Saturday's visitors will be looking to turn on the attacking style away from home once again.
Cambuur were left red-faced in their meeting with RKC Waalwijk on September 17 which ended in a comprehensive 5-1 thrashing at the Mandemakers Stadion.
Henk de Jong's men took the lead in the 17th minute through Jamie Jacobs but they were pegged back just past the half-hour mark by Michiel Kramer before second-half strikes from Zakaria Bakkali, Iliass Bel Hassani, Kramer and a Marco Tol own goal completed the turnaround.
As a result, the Yellow-Blues have now dropped down to bottom but one in the Eredivisie standings albeit only one point adrift of safety.
Currently the only side yet to pick up a point on home turf this term, Saturday's hosts will be eager to get going in front of their fans.
Cambuur Eredivisie form:
D
W
L
L
L
L
PSV Eindhoven Eredivisie form:
W
W
W
L
W
W
PSV Eindhoven form (all competitions):
W
W
L
D
W
W
Team News
Luuk de Jong remains sidelined for PSV Eindhoven due to a calf injury, and the Netherlands international is not expected to play any part this weekend.
Marco Van Ginkel and Noni Madueke are also unavailable owing to muscle and ankle injuries respectively, while Olivier Boscagli continues to battle with a knee problem.
Winger Cody Gakpo is definitely one to keep an eye on here having racked up 14 direct goal contributions in his seven league appearances so far.
Mees Hoedemakers and Alex Bangura were both sent off in Cambuur's defeat to Waalwijk, making them ineligible to participate in this one.
The hosts will also have to make do with the absence of Maxim Gullit, who has not featured since picking up a knee injury in February.
Cambuur possible starting lineup:
Virginia; Wermeskerken, Tol, Smand, Sambissa; Van Kaam, Breij, Paulissen; Balk, Uldrikis, Van der Water
PSV Eindhoven possible starting lineup:
Benitez; Mwene, Teze, Obispo, Max; Veerman, Til, Sangare; Saibari, Gakpo, Simons