Awaiting the winners of this tie in the grand finale is one of Feyenoord or Groningen, who go head-to-head in the other last-four encounter.
Match preview
SC Cambuur eased past the threat of Vitesse in the sides' quarter-final encounter on February 7 courtesy of a comprehensive 3-1 victory.
Henk de Jong's men opened the scoring through Milan Smit but were pegged back by Anis Hadj Moussa after which goals from Fedde De Jong and Smit got the job done.
However, the Yellow-Blues have picked up just four points from their four league matches since then and have dropped down to eighth place in the Eerste Divisie table.
Coming up next is the task of facing off against an opposing outfit who have only managed one win from the last six editions of this fixture.
Having let in 12 goals across their last five matches on home turf, Tuesday's hosts will need to tighten up at the back in front of their fans to give themselves a real shot at silverware here.
NEC ran out emphatic 3-0 winners against lower league side ADO Den Haag on February 6 to secure safe passage into the semi-final of the Dutch Cup.
Rogier Meijer's men got their noses in front through Koki Ogawa's early strike before second-half goals from Dirk Proper and Tjarron Chery sealed the deal.
The Eniesee claimed a 2-0 win over Sparta Rotterdam in their most recent league involvement and currently sit seventh in the Eredivisie table.
Unbeaten in eight of their last nine matches on the road across all competitions, Tuesday's visitors have proven themselves to be a tough nut to crack away from home of late.
Cambuur KNVB Beker form:
W
W
W
Cambuur form (all competitions):
D
W
D
L
W
L
NEC KNVB Beker form:
W
W
W
NEC form (all competitions):
D
W
W
L
D
W
Team News
NEC's Bas Dost is ruled out of this one through a heart problem, and the forward is still a considerable way off making a return to action.
Nils Rossen and Kas de Wit also miss out for the visitors, with the latter still yet to feature this term due to a long-term knee injury.
Milan Smit has scored five goals in his four cup appearances for Cambuur this term, making the Dutchman one to keep a close watch on here.
Dutch duo Gabi Caschili and Marcel Schaapman are both unavailable for selection as they continue to nurse respective knee injuries.
Cambuur possible starting lineup:
Van Osch; Poll, Bergsma, Smand, Ottesen; Van Kaam, Breij; Smit, De Jong, Balk; Uldrikis
NEC possible starting lineup:
Cillessen; Van Rooy, Sandler, Verdonk, Baas; Hoedemakers, Proper; Sano, Chery, Gonzalez; Ogawa