Off the back of victories in their respective last outings, the teams head into this weekend's encounter looking to pick up where they left off.
Match preview
Twente maintained their perfect record on home turf this term thanks to a comprehensive 3-0 victory over Groningen at De Grolsch Veste on Sunday.
Ron Jans's men failed to break the deadlock in the opening 45 minutes before putting on a superb second-half display to get the job done through strikes from Virgil Misidjan, Joshua Brenet and Ricky Van Wolfswinkel.
As things stands, The Tukkers remain fifth in the Eredivisie table but they have now moved to within four points of AZ Alkmaar in fourth place.
Next up is the task of facing off against an opposing outfit with just two victories in the previous 20 meetings between the teams dating back to 1992.
Winless in their last five games away from home across all competitions, Sunday's visitors set out to arrest their slump in form on enemy territory.
Cambuur secured safe passage into the next round of the KNVB-Beker following a 3-0 win over Rijnvogels at Sportpark de Kooltuin on Wednesday.
Off the back of a relatively uneventful first half, Pascal Bosschaart's men upped the ante after the restart courtesy of goals from Silvester van der Water, Milan Smit and Remco Balk.
Prior to that, The Yellow-Blues fell to a 3-0 defeat at the hands of Vitesse last Saturday and have now dropped to 14th in the league standings.
Having lost all but one of their five matches on home turf so far, Sunday's hosts will be keen to give their fans reason to cheer come the full-time whistle here.
Cambuur Eredivisie form:
L
L
L
W
D
L
FC Twente Eredivisie form:
W
D
L
W
L
W
Team News
Vaclav Cerny is suspended for this one after the forward received his marching orders in Twente's 2-0 defeat to Feyenoord a fortnight ago.
The visitors will also make the trip to Leeuwarden without Michal Sadilek as he remains out with a long-term injury which has seen him fail to feature since August.
Tom Boere has sat out each of Cambuur's last two matches with a muscle problem, making the 29-year-old a major doubt for this weekend's contest.
Dutchman Maxim Gullit is out of contention for the home side due to a knee injury, while Sekou Sylla continues to struggle with an ankle injury.
Cambuur possible starting lineup:
Virginia; Schmidt; Tol, Bergsma, Bangura; Jacobs, Paulissen, Van Kaam; Van der Water, Uldrikis, Mambimbi
FC Twente possible starting lineup:
Unnerstall; Smal, Propper, Hilgers, Brenet; Zerrouki, Vlap, Kjolo; Rots, Misidjan, Van Wolfswinkel