Eddie Howe's men were subjected to their first continental loss of the season against the German giants a fortnight ago, going down 1-0 at St James' Park to drop below Edin Terzic's men in the fascinating section.
Match preview
Even the fearsome Dortmund wall may have boarded their flights to Newcastle with a palpable sense of worry two weeks ago, having witnessed the Magpies tear French champions Paris Saint-Germain asunder on matchday two, but Terzic's rock-solid defence brought their hosts' momentum to a grinding halt.
A shadow of the side that put four goals past PSG, Newcastle had no answer to Dortmund's defensive might, and in the 45th minute of the contest, Nico Schlotterbeck charged down the other end of the field and laid the ball on a plate for Felix Nmecha to net the decisive goal.
Now level with Newcastle on four points in this year's group of death - sharing the Magpies' record of one win, one draw and one loss from their opening three battles so far - Dortmund have the edge over their English counterparts thanks to the head-to-head column, while leaders PSG are only two points better off than Terzic's crop.
A milestone will be hit for the German powerhouses this week, as they will become just the second Bundesliga side after Bayern Munich to play 150 games in the Champions League, but they were served a slice of humble pie by their Harry Kane-inspired superiors in Saturday's latest edition of Der Klassiker.
Indeed, a terrific treble from the England captain after Dayot Upamecano's early header condemned Dortmund to a harrowing 4-0 loss to the champions at Signal Iduna Park, as the hosts' eight-game unbeaten run across all tournaments came to an end in excruciating circumstances, and their vengeful opponents also know a thing or two about ending unblemished streaks.
Akin to their January slog with Arsenal, where perceived gamesmanship played its part in Newcastle coming away with a point in a 0-0 draw, a similar story unfolded on the defensive front during Saturday's showdown with the Gunners at St James' Park, as Howe's troops kept their Martin Odegaard-less visitors at bay with relative ease.
However, officiating controversy would inevitably rear its ugly head, as after Kai Havertz and Bruno Guimaraes narrowly avoided red cards during a bad-tempered end to the opening 45, Newcastle would consign Arsenal to their first top-flight loss of the season through Anthony Gordon's highly contentious winger.
An unprecedented three VAR checks delayed the St James' Park pandemonium, but with it being determined that the ball did not go out of play, Joelinton did not commit a foul on Gabriel Magalhaes and Gordon was not in an offside position, Newcastle's strike was confirmed, leading to Arteta launching a ruthless verbal assault on the standard of Premier League officiating at full time.
While steam continues to fire out of Gooners' ears, Newcastle rejoiced in another magnificent week, having also avenged last year's EFL Cup final loss to Manchester United by crushing the hopeless holders 3-0 at Old Trafford in the fourth round, and ending a 20-year streak without a Champions League away win is the next priority on Howe's in-tray.
That success did come against German opposition, though, as Sir Bobby Robson oversaw a 3-1 beating of Bayer Leverkusen in February 2003, and Howe could now follow in his late compatriot's footsteps as the next English manager to win a Champions League away game against a Bundesliga outfit.
Borussia Dortmund Champions League form:
L
D
W
Borussia Dortmund form (all competitions):
W
W
W
D
W
L
Newcastle United Champions League form:
D
W
L
Newcastle United form (all competitions):
D
W
L
D
W
W
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Team News
There were few positives indeed for Dortmund to take away from their four-goal crushing against Bayern, but Terzic did at least see his players emerge unscathed physically, leaving a total of three stricken athletes in the treatment room.
Emre Can continues to struggle with the hip issue that he picked up towards the end of the first half against Newcastle two weeks ago, while Mateu Morey and Julian Duranville are continuing their recoveries from knee and thigh injuries respectively.
None of Marius Wolf, Donyell Malen or Salih Ozcan lasted an hour in Der Klassiker, and the latter two's spots are certainly under threat from Karim Adeyemi and St James' Park matchwinner Nmecha, while a recall for Ramy Bensebaini at left-back could also be in order.
In contrast, the issues are beginning to pile up for Newcastle once again, as Jacob Murphy appeared to suffer a recurrence of his shoulder dislocation after coming off the bench against Arsenal, while Dan Burn tweaked his back during a heavy fall and was taken off at the break.
Matt Targett (hamstring), Alexander Isak (groin), Harvey Barnes (foot), Elliot Anderson (back), Sven Botman (knee) and Javi Manquillo (groin) are also in the care of the overworked Newcastle medical team, while the suspended Sandro Tonali will watch on from the stands once again.
With no Targett and potentially no Burn available at the Signal Iduna Park, Tino Livramento could be thrust into action at left-back after keeping Gabriel Martinelli quiet in the second half at St James' Park, although Lewis Hall represents another youthful alternative.
Borussia Dortmund possible starting lineup:
Kobel; Wolf, Hummels, Schlotterbeck, Bensebaini; Nmecha, Ozcan, Sabitzer; Reus, Fullkrug, Adeyemi
Newcastle United possible starting lineup:
Pope; Livramento, Schar, Lascelles, Trippier; Longstaff, Guimaraes, Joelinton; Almiron, Wilson, Gordon
We say: Borussia Dortmund 1-1 Newcastle United
Even with a double-figure absentee list, Newcastle's defensive diligence came to the fore against Arsenal, and a morale-depleted Dortmund side should not expect a repeat of their St James' Park triumph in front of the home crowd.