The Blues are currently 11th in the Championship table with 11 points, while the Lilywhites are 16th with nine points.
Match preview
Birmingham manager Lee Bowyer described his side's 3-0 defeat to Peterborough United last weekend as "not acceptable".
The result meant that the Blues suffered back-to-back losses for the first time this season, following a 4-1 defeat to Fulham three days earlier.
It was in stark contrast to their promising start to the campaign, in which they lost only one of their first six matches and conceded just three times.
Bowyer will hope that the last 10 days have just been a blip and that Birmingham can rediscover their early season form as the club aim to finish higher than 17th for the first time since 2016.
However, only relegated Rotherham United picked up fewer points at home in the Championship last season and the Blues have won just one of their first four at St. Andrew's in the new campaign.
Preston are yet to win away from home in the league this season, with only Peterborough United picking up fewer points on the road so far.
After opening the campaign with three successive defeats, Frankie McAvoy's men are now unbeaten in five Championship matches but have drawn their last three.
The Lilywhites held promotion-chasing West Bromwich Albion to a 1-1 draw last weekend, before progressing to the fourth round of the EFL Cup with a 4-1 win over Cheltenham Town in midweek.
Preston have won four of the last five games between the two sides, with Scott Sinclair the matchwinner in a 1-0 victory in their last meeting in January.
Should the Lancashire outfit be victorious again on Saturday, they would overtake Birmingham in the table and potentially climb into the top half for the first time this season.
Birmingham City Championship form:
Birmingham City form (all competitions):
Preston North End Championship form:
Preston North End form (all competitions):
Team News
Gary Gardner is suspended for Birmingham following his red card against Peterborough, meaning Ivan Sunjic will come into midfield.
The Blues will assess Marc Roberts ahead of Saturday after the defender was forced off at half time last weekend due to stomach pains; Dion Sanderson will deputise if Roberts is not available.
A strike partnership of Troy Deeney and Lukas Jutkiewicz was not that successful against the Posh, so one or both of Chuks Aneke and Scott Hogan could come in.
Preston pair Connor Wickham and Liam Lindsay both suffered injuries in the first half against Cheltenham in midweek so will be unavailable on Saturday.
Patrick Bauer suffered a broken nose last weekend and missed the cup encounter, but Frankie McAvoy says the defender will be "ready to go" at St. Andrew's.
Tom Barkhuizen and Scott Sinclair are back in training after recovering from illness, but they are unlikely to be thrown straight into the starting lineup.
Birmingham City possible starting lineup:
Sarkic; Colin, Sanderson, Dean, Pedersen; Chong, Woods, Sunjic, Bela; Jutkiewicz, Hogan
Preston North End possible starting lineup:
Iversen; Storey, Bauer, Hughes; van den Berg, Whiteman, Ledson, Earl; Johnson; Maguire, Jakobsen
We say: Birmingham City 0-0 Preston North End
Bowyer will demand a response from his team after two consecutive defeats, but Preston are proving hard to beat so the Blues' task will not be straightforward; we think all the signs point towards a fourth consecutive draw in the league for the Lilywhites.