Preview: Atletico Madrid vs. Inter Milan - prediction, team news, lineups

The Nerazzurri claimed a slender 1-0 first-leg victory at San Siro three weeks ago, courtesy of a late second-half strike from Marko Arnautovic.

Match preview

Following a bitterly disappointing group-stage exit in last season's Champions League, Atletico Madrid have at least gone one better this term by reaching the last 16, but their face an uphill battle to advance to their third quarter-final in five seasons following an underwhelming first-leg showing against Inter.

Indeed, just three days after beating Las Palmas 5-0 in La Liga, the Spanish outfit lacked a killer instinct in front of goal at San Siro and failed to register any of their seven shots on target before allowing Inter substitute Arnautovic to net a 79th-minute winner.

Diego Simeone, who represented Inter during his playing days, has come under pressure in recent weeks as his Atleti side have only won two of their last nine matches across all competitions, failing to score on five occasions during this run, including last weekend's 2-0 top-flight defeat at Cadiz.

Six points now separate Barcelona in third from fourth-placed Atletico, who are clinging on to their Champions League qualification spot as they sit just two points above fifth-placed Athletic Bilbao with 10 games remaining.

Atletico enter Wednesday's Champions League clash with Inter having failed to progress from any of their last three knockout ties after losing the first leg, but they will welcome a return to the Wanda Metropolitano where they have lost just one of their last 32 games in all tournaments, while they have also won seven of their last nine home encounters with Italian opposition.

In stark contrast to Atletico, Inter head to the Spanish capital in buoyant mood as they have won 14 and drawn one of their last 15 matches across all competitions, including a slender 1-0 away victory over Bologna in Serie A last weekend.

Simone Inzaghi opted to rest a few of his star names, including top scorer and captain Lautaro Martinez, but the Nerazzurri came out on top against their Champions League-chasing counterparts courtesy of a stooped header from Yann Aurel Bisseck towards the end of the first half.

After winning 12 Serie A games on the trot, Inter are firmly in the driving seat to win their 20th Scudetto as they sit pretty at the summit with 75 points from 28 matches, boasting a whopping 16-point lead over rivals AC Milan in second place.

With such an advantage, Inzaghi and co can shift all their focus to Wednesday's last-16 clash with Atletico in the Champions League, with last season's losing finalists seeking to go one better and lift their first European trophy since 2009-10.

Inter will be confident of securing their spot in the quarter-finals having progressed from seven of their last eight Champions League knockout ties after winning the first leg, but success against Atleti is not a given as the Nerazzurri have failed to win any of their last 10 visits to Spain in Europe's elite club competition.

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Inter Milan Champions League form:

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Team News

Atletico Madrid are hopeful that Antoine Griezmann and Jose Gimenez could both return to the matchday squad after missing each of the las for matches with respective ankle and thigh injuries, while Thomas Lemar (Achilles), Cesar Azpilicueta and Vitolo (both knee) all remain sidelined.

Either Gabriel Paulista or Stefan Savic is expected to start in central defence if Gimenez is not deemed fit to feature, while Nahuel Molina could replace Marcos Llorente at right wing-back.

A midfield triumvirate of Saul Niguez, Koke and Rodrigo De Paul is set to remain intact, while Alvaro Morata, who has scored just one goal in his last 10 appearances, could be joined in attack by Memphis Depay, who has netted only once in his last eight outings.

As for Inter Milan, first-leg hero Arnautovic is set to miss out with a hamstring injury, while Carlos Augusto tweaked his calf in last weekend's win at Bologna; both players join Juan Cuadrado (Achilles) and Stefano Sensi (ankle) in the treatment room.

Federico Dimarco is expected to take the place of Augusto at left wing-back, while Benjamin Pavard and Stefan de Vrij could replace Bisseck and Francesco Acerbi in central defence. Denzel Dumfries will also be pushing for a recall at right wing-back, but Inzaghi may decide to stick with Matteo Darmian.

Nicolo Barella, Hakan Calhanoglu and Henrikh Mkhitaryan are the most likely trio to start in centre-midfield, while top scorer Martinez, who has netted 26 times in all competitions including four goals in his last five appearances, is set to return to the first XI to partner Marcus Thuram up front.

Atletico Madrid possible starting lineup:

Oblak; Molina, Savic, Witsel, Hermoso, Lino; Saul, De Paul, Koke; Depay, Morata

Inter Milan possible starting lineup:

Sommer; Pavard, De Vrij, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Martinez

We say: Atletico Madrid 0-2 Inter Milan (Inter Milan to win 3-0 on aggregate)

Atletico can ill-afford another powderpuff performance in the final third if they wish to turn the tie around against a red-hot Inter side, who have looked unstoppable in recent months.

The momentum is certainly with the Italian visitors and although their record in Spain does not make for good reading, they have star names such as Martinez returning from a rest at the weekend to fire Inzaghi's side into the quarter-finals.

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