Both outfits enter the second leg on the back of 3-0 domestic wins, with the hosts seeing off Fulham while Ruben Amorim's men put Boavista to the sword.
Match preview
Sloppy goals and set-piece defending that left a lot to be desired were the themes of last week's first leg at the Estadio Jose Alvalade, where William Saliba nodded Arsenal in front before Goncalo Inacio responded in kind for Sporting with a header of his own from a corner.
Paulinho's tap-in 10 minutes into the second half would turn the tide in the hosts' favour, but when Arsenal needed a huge stroke of luck, Hidemasa Morita obliged, as Granit Xhaka's cross cannoned off the Japanese midfielder into the back of the net to cap off an all-action stalemate.
Undoubtedly a better result for Arsenal than Sporting heading into their Emirates encounter, Europa League success should certainly not define the Gunners' season as they continue to make waves in the Premier League, still five points clear at the summit thanks to the weekend's 3-0 beating of Fulham.
Only a catastrophic collapse would see Mikel Arteta's side not make their long-awaited Champions League return now, and an unprecedented Premier League and Europa League double is still on the cards for those in red and white, who are aiming to end a three-game drought without a win in Europa League knockout home games.
However, Sunday's sheer dominance at Craven Cottage saw Arsenal score at least two goals for the fourth game running, and they have posted four clean sheets in their last four Europa League home matches, keeping Villarreal, PSV Eindhoven, Bodo/Glimt and Zurich at bay in the process.
Ruing a poor miss from Paulinho which would have put his side out of sight in the second half, Sporting boss Amorim expressed his belief that his side's fortunes would soon be on the up following Thursday's entertaining stalemate, and he certainly got the response he was after domestically.
Nuno Santos's strike and a Salvador Agra own goal put Sporting two goals to the good in Sunday's Primeira Liga battle with Boavista before Paulinho came off the bench to net a third in injury time, but Amorim's fourth-placed men only succeeded in remaining 15 points behind Benfica in the rankings.
Seeking a first Europa League quarter-final berth since the 2017-18 campaign, when they were eliminated by eventual winners Atletico Madrid, Sporting take a seven-game unbeaten run in all tournaments to North London, and it has been 10 games since the Lions last failed to find the back of the net.
Leaving familiar territory behind does not phase Amorim's men either, as they can boast five successive away wins domestically and continentally ahead of the second leg, but not since 2005 have Sporting managed to come away from English soil with a victory.
Indeed, the visitors have failed to win in nine games in England since defeating Middlesbrough in the 2004-05 UEFA Cup - where they ended up reaching the final before losing to CSKA Moscow - but eliminating Midtjylland in the playoff round saw Sporting progress from a European tie when failing to win the first leg at home for the first time in 21 attempts.
Arsenal Europa League form:
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Arsenal form (all competitions):
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Sporting Lisbon Europa League form:
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Sporting Lisbon form (all competitions):
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Team News
A strong proponent of mind games, Arteta ruled both Leandro Trossard and Gabriel Jesus out of contention for Sunday's win over Fulham, but both attackers were ultimately given the green light to play - the latter coming off the bench for his first appearance since the World Cup.
However, there are fears that Eddie Nketiah's ankle problem could keep him sidelined until after the international break, while Mohamed Elneny remains out for the long-term following knee surgery.
Having hailed Fabio Vieira as Arsenal's most dangerous player in the first leg, Arteta ought to consider a recall for the Portugal native here, while Kieran Tierney, Jorginho, Emile Smith Rowe and Matt Turner - despite his shaky moments in the first leg - are also in line for starts.
As for Sporting, Amorim must cope without a couple of players on the naughty step, as Morita and Sebastian Coates both picked up their third bookings of the European campaign and will sit this one out through suspension.
On a brighter note, Manuel Ugarte is back from a ban of his own and should be a straight swap for Morita in the engine room, while Matheus Reis could be drafted into a central role to cover for Coates, allowing Santos to hold his spot at left-wing back.
Ex-Arsenal man Hector Bellerin will seemingly miss out on an Emirates reunion due to a knee injury - one of two absentees for the visitors alongside Daniel Braganca - but first-choice goalkeeper Antonio Adan is expected to shake off a muscle problem that kept him out of the win over Boavista.
Arsenal possible starting lineup:
Turner; Tomiyasu, Saliba, Gabriel, Tierney; Jorginho, Partey, Vieira; Nelson, Trossard, Smith Rowe
Sporting Lisbon possible starting lineup:
Adan; St. Juste, Inacio, Reis; Esgaio, Ugarte, Goncalves, Santos; Edwards, Paulinho, Trincao
We say: Arsenal 2-1 Sporting Lisbon (Arsenal win 4-3 on aggregate)
As Arteta alluded to after the first leg, the Spaniard's side are conceding too many easy goals at present, and a rejigged defence may not experience much luck against a clinical Sporting frontline.