The Gunners can surge eight points clear at the top of the table with victory, while the Eagles gave Patrick Vieira the boot on Friday amid a 12-game winless run.
Match preview
On Thursday night, one of the greatest if not the greatest goal ever scored at the Emirates Stadium flew into the back of the net from 46 yards, but unfortunately for Arsenal, it was one that proved to be the catalyst for more Europa League heartache.
Fresh from a 2-2 draw in the first leg of their last-16 clash with Sporting Lisbon, Granit Xhaka sent Arsenal ahead before Pedro Goncalves caught Aaron Ramsdale off his line with an unbelievable long-range strike, forcing extra time and a penalty shootout in which Gabriel Martinelli fluffed his lines from 12 yards.
Some glass-half-full Gunners fans were quick to label their continental exit as a blessing in disguise - a sentiment not shared by Mikel Arteta - as the surprise Premier League title contenders focus all their efforts on keeping Manchester City at bay during the business end of the season.
An extremely comfortable 3-0 success at Fulham last weekend - Arsenal's fifth Premier League win on the bounce - saw them maintain their five-point lead over the champions, and that advantage will extend to eight with a win as Pep Guardiola's side compete in the FA Cup quarter-finals.
Scoring at least three goals in four of their last five Premier League matches, Arteta has implored his side to immediately bounce back from their European misery, but a different kind of bounce may be in effect for their capital counterparts in the wake of the division's latest sacking.
The St Patrick's Day witticisms were out in full force when Crystal Palace relieved Patrick Vieira of his duties on March 17, as the 46-year-old - along with coaches Osian Roberts, Kristian Wilson and Said Aigoun - departed following an ugly 12-game winless run in 2023.
A 1-0 defeat to Brighton & Hove Albion on Wednesday - courtesy of a Solly March strike - proved to be the final nail in the Frenchman's coffin, but Palace at least managed to snap their horrendous streak of failing to have a shot on target in three Premier League games on the South Coast.
As the Eagles board search high and low for a replacement - with goalkeeping coach Dean Kiely still in his job - Palace's on-field recruits can only pray for an immediate new manager bounce to come into effect at the Emirates, as they are entrenched in 12th place in the table and only three points clear of the drop zone.
Not since overcoming Bournemouth on New Year's Eve have the Eagles prevailed in any competition - losing four and drawing one of their last five Premier League away games - and their unwanted streak without a goal now stands at four games, but the Emirates is often a kind ground to those in blue and red.
Indeed, Palace have avoided defeat in their last four Premier League away games at Arsenal - throwing away two points in a 2-2 draw last season courtesy of Alexandre Lacazette's late leveller - but the Gunners opened the new top-flight campaign with a straightforward 2-0 win at Selhurst Park back in August.
Arsenal Premier League form:
L
W
W
W
W
W
Arsenal form (all competitions):
W
W
W
D
W
L
Crystal Palace Premier League form:
D
D
D
L
L
L
Team News
As if 120 gruelling minutes of Europa League action was not undesirable enough, Arsenal lost both of Takehiro Tomiyasu (knee) and William Saliba (back) to injury in the first half on Thursday night, and Arteta is concerned that the former may have sustained another serious issue.
The severity of Saliba's concern is not yet known, but Rob Holding can expect a rare Premier League start in his likely absence, while Eddie Nketiah and Mohamed Elneny will welcome the defensive duo into the infirmary.
Gabriel Jesus completed 45 minutes on his first start since the World Cup on Thursday, but a demotion to the bench now seems likely as Leandro Trossard - who made history with three first-half assists at Craven Cottage - spearheads the charge.
Meanwhile, whoever takes charge of Palace this weekend must cope without the services of Arsenal loanee Albert Sambi Lokonga, who cannot face his parent club, but Will Hughes and/or James McArthur could return from illness to soften the blow.
With Sam Johnstone still nursing a calf problem and Vicente Guaita dealing with a hamstring strain, 19-year-old academy graduate Joe Whitworth could make back-to-back Premier League starts in goal, while defender Nathan Ferguson is still building up his match fitness.
Fresh from being recalled to the England squad, Marc Guehi will offer protection to the teenage shot-stopper, as Cheick Doucoure mans the engine room after somehow escaping a second yellow card at the Amex.
Arsenal possible starting lineup:
Ramsdale; White, Holding, Gabriel, Tierney; Odegaard, Partey, Xhaka; Saka, Trossard, Martinelli
Crystal Palace possible starting lineup:
Whitworth; Clyne, Andersen, Guehi, Mitchell; Hughes, Doucoure, Schlupp; Olise, Edouard, Zaha
We say: Arsenal 2-0 Crystal Palace
Understandably fearing the classic new manager bounce given what happened against Sean Dyche's Everton, such concerns from Gooners should prove unfounded against a shot-shy Palace side rocked by a change in the hierarchy.