Having already established a two-goal lead from the first leg, the home side are in pole position to finish the job in front of their fans.
Match preview
Anderlecht breezed past the challenge of Paide in last Thursday's encounter at A. Le Coq Arena which ended in a comfortable 2-0 victory.
First-half goals from Lior Refaelov and Fabio Silva got the job done for Felice Mazzu's men in a largely one-sided affair in Tallinn.
Les Mauves et Blancs claimed a resounding 3-1 win over Seraing in their subsequent league involvement and now sit second in the Jupiler Pro League standings.
Next up on the horizon for the Brussels-based club is the conclusion of their European assignment in regards to which they already have one hand on the prize.
Having won six of their most recent seven home games, Thursday's hosts will be widely expected to secure another impressive result on their own patch.
Paide failed to make home advantage count in their clash with Anderlecht where they fell to a ghastly, albeit not by any means, fatal defeat.
The Estonian side went toe to toe with their most illustrious opponents for the majority of the contest but were unable to land any significant blow.
Just as they managed in their last continental continental affair away from home, Karel Voolaid's men would need to at least score three times to complete a remarkable turnaround in the Belgian capital.
Thursday's visitors would also need to keep their hosts at bay in front of goal which looks to be a highly insurmountable task as Anderlecht have netted 16 times in seven games since they last failed to score on home turf.
Anderlecht Europa Conference League form:
Anderlecht form (all competitions):
Paide Europa Conference League form:
Paide form (all competitions):
Team News
Fabio Silva has continued his fantastic start to life in an Anderlecht shirt with three goals in his opening four games, making him one to look out for here.
Sebastiano Esposito was given to nod to partner Silva in attack over the weekend but the Italian could be dropped to the bench for this one.
With no fresh injury or suspension concerns for Paide to note, we expect Karel Voolaid to name the same starting lineup from the first leg.
This would see the 37-year-old goalkeeper Mihkel Aksalu fend off competition from Ebrima Jarju to retain his place between the sticks.
Anderlecht possible starting lineup:
Van Crombrugge; Delcroix, Hoedt, Debast; Amuzu, Ait El Hadj, Arnstad, Verschaeren, Murillo; Silva, Refaelov
Paide possible starting lineup:
Aksalu; Frolov, Razak, Klavan, Saliste; Mool, Simon; Luts, Saag, Tambedou; Singateh