But while they'll be no repeat of last season's final day championship madness, there are still plenty of teams waiting to find out their fates.
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Here, talkSPORT.com breaks down the permutations for clubs at both ends of the table vying to improve their league standings this week.
What can still be decided in the Premier League's final week?
Champions League places
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Man City have claimed a third successive title with Arsenal confirmed as runners-up and both will head into Europe's top competition next season.
The battle for the last two spots in the top four is down to three teams, with Newcastle the closest to booking their Champions League place.
Should the Foxes win then Eddie Howe's men would then need to at least draw away at Chelsea on the final day to seal a return to the Champions League for the first time in 20 years.
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Manchester United are in the same boat as Newcastle, needing just a solitary point from a possible six in their last two games.
But the Red Devils will need to wait until Thursday at the earliest when they host Chelsea, before a second opportunity comes against Fulham.
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Liverpool will know if their top four chances are over by the time they are next in action against Southampton on Sunday.
Should one or both of Newcastle and United lose their penultimate match then the Reds would need to beat the relegated Saints and hope the two teams above them lose again.
Jurgen Klopp's men would also require a seven-goal swing if Newcastle are the team they catch on 69 points.
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Europa League places
Brighton are all-but mathematically assured of a Europa League spot having risen to sixth following their 3-1 win over Southampton.
The Seagulls are three points above Aston Villa - the only team that can move onto their 61 point tally - but also have a game in hand.
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A draw in either of Brighton's last two matches, at home to Man City on Wednesday and against Villa themselves on the final day, eliminates all doubt.
But for arguments sake, Roberto De Zerbi's men could be overhauled should they lose both games with a goal difference swing of 16.
Europa Conference League places
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Tottenham dropped out of European contention entirely following their 3-1 defeat to Brentford.
Europa League football is now out of reach but Spurs are still within a chance of finishing seventh for a place in UEFA's third tier.
The north Londoners would need to beat Leeds on Sunday and hope Villa above them fail to win against Brighton.
A draw would also just be enough for Tottenham to end seventh on goals scored should Villa lose to the Seagulls.
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A West Ham victory in the Europa Conference League final against Fiorentina has no bearing on the top seven places domestically.
The Hammers will earn a place in next season's Europa League with victory in Prague despite finishing in the bottom half of the Premier League table but that would see England have eight representatives in 2023/24.
Relegation
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Southampton are the only club to have been relegated and there are still two spots from the trio of Leicester, Leeds and Everton to be decided this week.
Leicester are currently 19th on 30 points, and the Foxes need two wins from their last two games to guarantee their survival.
Should the 2015/16 Premier League champions draw or lose to Newcastle, then they would need to beat West Ham on the final day and hope results elsewhere go their way.
Everton, who have an inferior goal difference to Leicester, will know whether their future remains in their hands after the result at St James' Park.
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The Toffees host Bournemouth on the final day while Leeds take on Tottenham needing to rely on other results regardless.