The Selecao kicked off their World Cup campaign on a high as they claimed a 3-2 victory over Ghana, with Cristiano Ronaldo, Joao Felix and Rafael Leao getting on the scoresheet to sink the Black Stars last Thursday.
While Fernando Santos's side are one win away from securing a fourth knockout-stage appearance, Uruguay will set out to get their campaign back on track after playing out a somewhat disappointing goalless draw in their opener against South Korea.
Here, Sports Mole looks at how the squads of Portugal and Uruguay stack up against each other ahead of Monday's matchup.
PORTUGAL
Most valuable player:
Rafael Leao (£73.5m)
Overall squad value:
£810.2
Most capped player:
Cristiano Ronaldo (192)
Leading goalscorer:
Cristiano Ronaldo (118)
Total caps:
1,084
Total goals:
199
Oldest player:
Pepe (39)
Youngest player:
Antonio Silva (19)
Average age:
26.8
SQUAD IN FULL
Goalkeepers: Diogo Costa (Porto), Jose Sa (Wolverhampton Wanderers FC), Rui Patricio (Roma)
Defenders: Diogo Dalot (Manchester United), Joao Cancelo (Manchester City), Danilo Pereira (Paris Saint-Germain), Pepe (Porto), Ruben Dias (Manchester City), Antonio Silva (Benfica), Nuno Mendes (Paris Saint-Germain), Raphael Guerreiro (Borussia Dortmund)
Midfielders: Joao Palhinha (Fulham), Ruben Neves (Wolverhampton Wanderers), Bernardo Silva (Manchester City), Bruno Fernandes (Manchester United), Joao Mario (Benfica), Matheus Nunes (Wolverhampton Wanderers), Vitinha (Paris Saint-Germain), William Carvalho (Real Betis), Otavio (Porto)
Forwards: Cristiano Ronaldo (Manchester United), Joao Felix (Atletico Madrid), Rafael Leao (AC Milan), Ricardo Horta (Braga), Goncalo Ramos (Benfica), Andre Silva (RB Leipzig)
URUGUAY
Most valuable player:
Federico Valverde (£86.2m)
Overall squad value:
£388m
Most capped player:
Diego Godin (160)
Leading goalscorer:
Luis Suarez (68)
Total caps:
1198
Total goals:
173
Oldest player:
Diego Godin (36)
Youngest player:
Facundo Pellistri (20)
Average age:
27.8
SQUAD IN FULL
Goalkeepers: Fernando Muslera (Galatasaray), Sergio Rochet (Nacional), Sebastian Sosa (Independiente)
Defenders: Diego Godin (Velez Sarsfield), Jose Gimenez (Atletico Madrid), Martin Caceres (LA Galaxy), Sebastian Coates (Sporting Lisbon), Matias Vina (Roma), Ronald Araujo (Barcelona), Guillermo Varela (Flamengo), Mathias Olivera (Napoli), Jose Luis Rodriguez (Nacional)
Midfielders: Matias Vecino (Lazio), Rodrigo Bentancur (Tottenham Hotspur), Federico Valverde (Real Madrid), Giorgian de Arrascaeta (Flamengo), Lucas Torreira (Galatasaray), Nicolas de la Cruz (River Plate), Manuel Ugarte (Sporting)
Forwards: Luis Suarez (Nacional), Edinson Cavani (Valencia), Maxi Gomez (Trabzonspor), Darwin Nunez (Liverpool), Facundo Torres (Orlando City), Facundo Pellistri (Manchester United), Agustin Canobbio (Athletico Paranaense)
Read more on Portugal vs Uruguay
Click here to read our full preview for Portugal vs Uruguay
How Portugal could line up against Uruguay
How Uruguay could line up against Portugal
World Cup 2022: Reasons for Portugal to be confident of beating Uruguay