Robert Page's Dragons face five games in quick succession in early June including their vital World Cup play-off final against either Scotland or Ukraine at the weekend.
Before that Cardiff showdown, Gareth Bale and co will head to Wroclaw as the Nations League gets back underway.
The Welsh take on Poland, Belgium and the Netherlands in their tricky group.
They will want to use Wednesday's game as a warm-up for the key World Cup play-off on Sunday.
Poland v Wales: talkSPORT coverage
This Nations League Group A4 tie will take place on Wednesday, June 1.
Kick-off at the Stadion Miejski Wroclaw is set for 5pm UK time
talkSPORT 2 will have full coverage from 4pm and commentary will be provided by Nigel Adderley and former Wales striker Dean Saunders.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream. You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Poland v Wales: Team news
Wales squad
Goalkeepers: Hennessey, Ward, A Davies
Defenders: B Davies, Rodon, Mepham, Gunter, Norrington-Davies, Roberts, N Williams, Denham
Midfielders: Allen, Morrell, Ampadu, Smith, Ramsey, Levitt, Matondo, Thomas, Colwill, Wilson, J Williams, Burns
Forwards: Bale, James, Harris, Moore, Johnson
Poland v Wales: What has been said?
Brennan Johnson is set to start for Wales as Page looks to rest the likes of Bale, Aaron Ramsey and Joe Allen for the play-off final.
But Page is excited to see what the Nottingham Forest forward can do on the international stage.
Page said: "Brennan is the future of Welsh football and I think he's top-six (Premier League) now.
"He's shown he's got that potential and ability.
"I've seen it in him for a long time and it's been great to watch his development.
"I'm going to use these Nations League games as a tool to give the Brennan Johnsons of the world an opportunity, expose them to top players and top teams.
"The Nations League is not the be-all and end-all. It's about exposing the younger players to opposition like that.
"So in 12 months, or two years' time, when we're in an important game for the World Cup or the Euros, these players will have benefited from this experience and may be the one to score the winner to get us through."