It was an emphatic night of Champions League action on Tuesday, as Liverpool thrashed FC Porto 5-1 and Lionel Messi scored his first Paris Saint Germain goal in a 2-0 victory against Manchester City.
One of the competitions greatest ever shocks occurred as Champions League debutants Sheriff Tiraspol beat Real Madrid 2-1 at the Santiago Bernabeu, and Atletico Madrid came from behind in the dying moments to take all three points against AC Milan at the San Siro.
Wednesday's games see both Chelsea and Manchester United get amongst the action, and both sides will be keen to get back to winning ways after the pair suffered 1-0 defeats at home in the Premier League on Saturday.
BetVictor Brand Ambassador Michael Owen has given his predictions ahead of Wednesday's action, including a "must-win" game for Ole Gunnar Solskjaer's side.
Manchester United's "must-win" clash with Villarreal
Michael Owen predicts Manchester United 2-0 Villarreal
Manchester United lost to Villarreal in the Europa League final back in May
United's Champions League got off to the worst possible start as they surrendered an early lead against Young Boys and lost the tie 2-1 in Switzerland, making their clash with Villarreal a must win game.
To add extra fuel to the fire, it's a replay of last seasons Europa League final, where Villarreal prevailed following a lengthy penalty shootout, as United had to settle for a runners-up medal.
Owen told BetVictor : "This is a must-win for United after some disappointing results. The defeat to Young Boys on match day one was a shock and ultimately one that Solskjaer must feel was preventable.
"Ronaldo's signing galvanised the club but after a couple of bad results, the pressure is back on Ole. Villarreal are an organised side but have had a strange start to their La Liga season, drawing five of their first six.
"Unai Emery is obviously an experienced manager in Europe, but I think United will have too much for them. I'm going for a 2-0 United win."
Chelsea's to respond against Juventus
Michael Owen predicts Juventus 0-1 Chelsea
Romelu Lukaku was the difference in Chelsea's last Champions League game against Zenit
Romelu Lukaku stepped up in Chelsea's Champions League opener as the Belgian finally found the breakthrough against a resilient Zenit side to guide the Blues to a narrow 1-0 victory.
Chelsea will be keen to bounce back after suffering their first loss of the season on Saturday, as Pep Guardiola's City finally got the better of Thomas Tuchel at the fourth time of asking, as Gabriel Jesus scored the only goal of the game at Stamford Bridge.
Juventus are Chelsea's biggest threat on paper in their Champions League group, but both Alvaro Morata and Paulo Dybala have been ruled out for Wednesday's clash, leaving the Old Lady short of attacking options.
Owen said: "I've got to say, I didn't see that performance against Man City coming. That was a rare poor showing from Chelsea under Tuchel, but I'd expect him to get a response from his side here.
"I still think Chelsea have a good chance of retaining this trophy. Juventus have started their Serie A season in poor form and frankly, don't look quite the side they once were.
"I would never write them off, particularly with Allegri back at the helm, but I fancy Chelsea to come back from Turin with a win. 1-0 Chelsea is my prediction."