During their 1-1 draw with Chelsea before the international break, the Garibaldi saw James Ward-Prowse take the walk of shame for two bookable offences, meaning that he has incurred a one-match ban.
In addition. Morgan Gibbs-White has been slapped with an extra suspension after admitting to an improper conduct charge from the fiery draw with Brighton & Hove Albion in September, although he hurt his ankle in the Chelsea clash anyway.
As well as the two banned players, Santo himself is serving a three-game touchline suspension after landing himself in hot water with the FA, while Ibrahim Sangare (thigh) and Danilo (ankle) are both injured.
Gibbs-White is arguably irreplaceable in the Forest setup, but Anthony Elanga should be summoned to replace him as Elliot Anderson switches to a central role; Callum Hudson-Odoi and Chris Wood are shoo-ins up top.
Nicolas Dominguez is the prime candidate to take Ward-Prowse's place in midfield alongside captain Ryan Yates, and Santo did not name check Matz Sels - who withdrew from this month's Belgium squad - when giving his pre-game injury update.
As a result, the Forest number one should be fine to don the gloves behind a settled back four of Ola Aina, Alex Moreno, Nikola Milenkovic and Murillo.
Nottingham Forest possible starting lineup:
Sels; Aina, Murillo, Milenkovic, Moreno; Yates, Dominguez; Hudson-Odoi, Anderson, Elanga; Wood