The Dutch manager led the Netherlands to Euro 2017 glory and will be reliving some great memories as she sees familiar faces.
Of course, Wiegman is now in charge of the Lionesses and this will be the first time she returns to face her former side.
England head into the game off the back of a 2-1 win over Scotland last week in their opening game of the competition.
And they'll be confident of adding another three points as they aim to continue their incredible form, losing only one of their last 31 games under Wiegman.
Netherlands vs England: How to follow
This Women's Nations League tie will take place on Tuesday, September 26.
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Kick-off at Stadium Galgenwaard in Utrecht is scheduled for 7pm.
The game will be shown live and free-to-air on ITV4 with coverage beginning at 6:15pm.
talkSPORT and talkSPORT.com will keep you up to date with all the latest.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
ou can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Netherlands vs England: Team news
Wiegman has everyone in the England squad available for this clash.
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Alessia Russo was a slight doubt but after being given some extra time off, she is now available to play for the Lionesses.
England squad
Goalkeepers: Mary Earps (Manchester United), Hannah Hampton (Chelsea), Ellie Roebuck (Manchester City)
Defenders: Millie Bright (Chelsea), Lucy Bronze (Barcelona), Jess Carter (Chelsea), Niamh Charles (Chelsea), Alex Greenwood (Manchester City), Esme Morgan (Manchester City), Maya Le Tissier (Manchester United), Lotte Wubben-Moy (Arsenal)
Midfielders: Laura Coombs (Manchester City), Jordan Nobbs (Aston Villa), Jess Park (Manchester City), Lucy Staniforth (Aston Villa), Georgia Stanway (Bayern Munich), Ella Toone (Manchester United), Katie Zelem (Manchester United)
Forwards: Rachel Daly (Aston Villa), Lauren Hemp (Manchester City), Lauren James (Chelsea), Chloe Kelly (Manchester City), Katie Robinson (Brighton & Hove Albion), Alessia Russo (Arsenal)
Netherlands vs England: What has been said?
England boss Wiegman is delighted to be heading back to her home country for this Women's Nations League clash.
"Of course, I have some memories here and so do the English. It's very nice being here," said Wiegman.
"It's just very special. We know each other really well. I know most of the staff, the players and it's in the Netherlands so lots of people will be in the stands.
"When we arrived, we have some memories that came back.
"Of course, you have to move on. We have a big game so we have to focus on that game."