After the glory of claiming a first Scudetto in over three decades last season, Napoli have been unable to replicate that success, with their hopes of even finishing in the top four looking slim as they are now on their third permanent manager of the season in Francesco Calzona.
Juve's hope of a first Scudetto in four seasons also appear to be over given Inter Milan's form, ahead of a fixture that has so often got them over the line when chasing titles over the past decade.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides.
Head-to-head record
Previous meetings: 181
Napoli wins: 46
Draws: 50
Juventus wins: 85
It was Napoli who got the better of the Old Lady last season in their two key battles which proved that Luciano Spalletti's men were the best in the land.
Before their 10-point deduction and in the midst of an excellent run of form, Juventus travelled to the Maradona with hopes of closing the gap, but were blown away as Victor Osimhen and Khvicha Kvaratskhelia put on a masterclass in 5-1 Napoli win last January.
Massimiliano Allegri's side never truly recovered from that humbling, and when they were beaten again by the Partenopei on home soil in April thanks to Giacomo Raspadori's late strike, that virtually sealed the title for Napoli.
That has not been the only season where this fixture has played a big role in deciding the champions though, as the two have had intense battles on more than one occasion in recent times when both chasing the Serie A title.
Juventus' 2-1 win here in Naples in March 2019 helped to keep their opponents at arms length as they raced to an eighth straight title, while an injury-time winner from Kalidou Koulibaly at the Allianz Stadium in April 2018 was not enough for Napoli, who still finished second behind the Bianconeri despite finishing on 91 points.
Sandwiched in between those two clashes was arguably the game of the season early in the 2018-19 campaign, when Juventus let a 3-0 lead slip, but still won thanks to Koulibaly putting through his net this time, again on 90 minutes, to hand the Old Lady a 4-3 win.
Less entertaining, but hugely significant was the Coppa Italia final played between these two sides in front of an empty Stadio Olimpico in 2020, which Napoli won 4-2 on penalties after 120 minutes of goalless action.
There have been other Coppa clashes involving the two, but the most dramatic cup tie between Napoli and Juve came in the 1988-89 UEFA Cup quarter-finals, where Diego Maradona inspired his side to a phenomenal comeback.
There was a 5-3 win for Napoli at the Stadio Vittorio Pozzo and a 4-2 success for Juve at the San Paolo in their two Serie A meetings that season, but even they could not compare to the jubilation seen in the UEFA Cup clashes.
Two-nil down from the first leg, Napoli roared back in front of 89,000 adoring supporters to beat Juventus 3-0 after extra time, on their way to lifting the trophy that season.
Back to more recent times, Juventus will look to complete a league double over Napoli this weekend, having already beaten the Neapolitans back in December thanks to Federico Gatti's goal, but they have lost on their last four visits here.
Last 20 meetings
Dec 08, 2023: Juventus 1-0 Napoli (Serie A)
Apr 23, 2023: Juventus 0-1 Napoli (Serie A)
Jan 13, 2023: Napoli 5-1 Juventus (Serie A)
Jan 06, 2022: Juventus 1-1 Napoli (Serie A)
Sep 11, 2021: Napoli 2-1 Juventus (Serie A)
Apr 07, 2021: Juventus 2-1 Napoli (Serie A)
Feb 13, 2021: Napoli 1-0 Juventus (Serie A)
Jan 20, 2021: Juventus 2-0 Napoli (Supercoppa Italiana)
Jun 17, 2020: Napoli 0-0 Juventus (4-2 pens) (Coppa Italia Final)
Jan 26, 2020: Napoli 2-1 Juventus (Serie A)
Aug 31, 2019: Juventus 4-3 Napoli (Serie A)
Mar 03, 2019: Napoli 1-2 Juventus (Serie A)
Sep 29, 2018: Juventus 3-1 Napoli (Serie A)
Apr 22, 2018: Juventus 0-1 Napoli (Serie A)
Dec 01, 2017: Napoli 0-1 Juventus (Serie A)
Apr 05, 2017: Napoli 3-2 Juventus (Coppa Italia Semi-Final second leg)
Apr 02, 2017: Napoli 1-1 Juventus (Serie A)
Feb 28, 2017: Juventus 3-1 Napoli (Coppa Italia Semi-Final first leg)
Oct 29, 2016: Juventus 2-1 Napoli (Serie A)
Feb 13, 2016: Juventus 1-0 Napoli (Serie A)
Last 10 Serie A meetings
Dec 08, 2023: Juventus 1-0 Napoli (Serie A)
Apr 23, 2023: Juventus 0-1 Napoli (Serie A)
Jan 13, 2023: Napoli 5-1 Juventus (Serie A)
Jan 06, 2022: Juventus 1-1 Napoli (Serie A)
Sep 11, 2021: Napoli 2-1 Juventus (Serie A)
Apr 07, 2021: Juventus 2-1 Napoli (Serie A)
Feb 13, 2021: Napoli 1-0 Juventus (Serie A)
Jan 26, 2020: Napoli 2-1 Juventus (Serie A)
Aug 31, 2019: Juventus 4-3 Napoli (Serie A)
Mar 03, 2019: Napoli 1-2 Juventus (Serie A)