The Red Devils lost to Aston Villa last time out in the top-flight but have been buoyed by a late Cristiano Ronaldo winner against Villarreal in midweek.
And Ole Gunnar Solskjaer could wish for no better opponent for his side to build on that Champions League victory than Everton this weekend.
The Old Trafford outfit have lost just one of their last 12 Premier League meetings with Everton, winning six and drawing five.
Their sole defeat was a 4-0 loss at Goodison Park in April 2019 in which the Merseysiders inflicted United's fifth consecutive away defeat.
Everton's record at Old Trafford is even worse, despite the fact that the Toffees won their first ever Premier League away trip to United in 1992.
Since then, Rafael Benitez's side have won just one of their 28 trips to Manchester, drawing seven and losing 20!
Their only victory came back in December 2013, where Bryan Oviedo struck four minutes from time when former Everton boss David Moyes was in charge of United for a single season.
Benitez doesn't boast a good record at the Theatre of Dreams either, as the Spaniard has lost seven of his nine top-flight away games against United.
The 61-year-old's two wins - as many as Everton have in Premier League history - came during charge of Liverpool and Chelsea respectively.
However, Benitez, who bossed the Reds' 4-1 win in 2009 and Chelsea's 1-0 victory in 2013, could become the first ever manager to beat United away with three different clubs.
But the ex-Newcastle gaffer will have to perform a miracle with a number of his key stars still injured including Dominic Calvert-Lewin.
This fixture did finish in a thrilling 3-3 draw last season and Everton will leapfrog United in the league if they manage to inflict a famous win.