The Whites welcome the Championship side to Elland Road looking to progress to the next stage of the competition.
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Jesse Marsch's men came from two goals down in south Wales to draw 2-2, with Rodrigo and Sonny Perkins helping their side to earn a replay, with fans still left unimpressed.
Klich will say his goodbyes one last time to Leeds fans, before then leaving the club to join Wayne Rooney's DC United in America.
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It will bring an end to his six-year tenure at Elland Road, having won the Championship title in 2020.
Leeds posted a cryptic tweet on Twitter, which read: "Advice for tonight: Make sure you're in your seats early," followed by a Poland flag.
Klich wasted no time by providing a tongue-in-cheek comment that international team-mate Robert Lewandowski is set to join the Whites from Barcelona.
Responding to the Whites' post, Klich replied: "Good luck @lewy_official, it is amazing club you will love it."
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A guard of honour, complete with 'Klich 43' shirts worn by the squad and staff, followed his final appearance for Leeds against West Ham on January 4.
The 32-year-old broke down on the pitch in front of those who had remained to applaud him at the final whistle.
But rather than see a Lewandowski unveiling, Klich is set to be paraded on the pitch before the kick-off.
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Should Leeds they get past Cardiff on Wednesday night, a tie against either Boreham Wood or Accrington Stanley awaits them.