Pep Guardiola's champions currently sit ten points clear of Thomas Tuchel's side with another defeat for the Blues surely ending their title charge.
City's 4-1 FA Cup victory over Swindon Town was the club's seventh in a row in all competitions while Chelsea are on a three-match win streak of their own.
Man City v Chelsea: talkSPORT commentary
This Premier League clash is set to take place on Saturday, January 15th at the Etihad with kick-off scheduled for 12:30pm UK time.
The game will be live and exclusive on talkSPORT with Hugh Woozencroft serving as your presenter once coverage starts at 11am.
Commentary will then come from from Sam Matterface, former Manchester City winger Trevor Sinclair and former Chelsea defender Scott Minto.
City beat Chelsea 1-0 in the reverse fixture at Stamford Bridge back in September and haven't lost in the league since the end of October.
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Man City v Chelsea: Team news
The hosts were forced to deal with a COVID-19 outbreak prior to their win over Swindon and it remains to be seen which players are still out.
John Stones is close to returning to full fitness following a knock but Riyad Mahrez remains away on Africa Cup of Nations duty with Algeria.
As for Chelsea, Tuchel has no fresh injury concerns with Ben Chilwell, Reece James and Trevoh Chalobah all still on the sidelines.
AFCON representative Edouard Mendy remains unavailable but both Thiago Silva and N'Golo Kante returned to action against Spurs on Wednesday.
Man City v Chelsea: What has been said?
Tuchel was quizzed over whether he'd continue to utilise a back four following Chelsea's Carabao Cup win over Tottenham.
He said: "Both games were very commited to the structure and very disciplined.
"Credit to the team they are ready for some adjustment and gives us more options and makes us a bit less predictable.
"It's good to have these options but it needs to fit what we expect and the spaces we need to find. Then we will decide from match to match."