Ole Gunnar Solskjaer's side have endured a frustrating few weeks but will have rebuilt their confidence with a late 3-2 victory over Atalanta in the Champions League.
For Jurgen Klopp's side morale won't be an issue with the Reds unbeaten so far this season.
Premier League clash to kick-off at Old Trafford at 4:30pm
Man United XI | De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Bruno Fernandes, Rashford, Greenwood, Cristiano Ronaldo
Subs | Henderson, Bailly, Pogba, Lingard, Dalot, Cavani, Sancho, Matic, Van de Beek
Liverpool XI | Alisson, Alexander-Arnold, Van Dijk, Konate, Robertson, Keita, Milner, Henderson, Jota, Firmino, Salah
Subs | Adrian, Mane, Gomez, Oxlade-Chamberlain, Jones, Minamino, Tsimikas, Origi, Matip
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