The Red Devils have endured a mixed run of recent results but only need a point from their last two games to finish in the top four.
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Erik ten Hag has seen his side recover from successive defeats to record back-to-back wins that has left them in the driving seat.
The most recent of which, a 1-0 victory over Bournemouth, coupled with Liverpool's 1-1 draw with Aston Villa, has left them all-but certain to return to Europe's elite competition.
Chelsea make a second trip to Manchester in less than a week having suffered a 1-0 defeat to champion City's second-string team.
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The latest humiliating result left the Blues in 12th, with Frank Lampard overseeing seven defeats and only one win in nine games.
Man United vs Chelsea: talkSPORT coverage
This Premier League clash will be played on Thursday, May 25.
Kick-off at Old Trafford is scheduled for 8pm.
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talkSPORT will have EXCLUSIVE live coverage from Manchester with our coverage presented by Hugh Woozencroft.
Commentary will then come from Nigel Adderley and former England striker Dean Ashton.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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Man United vs Chelsea: Team news
The hosts are expected to welcome back top goalscorer Marcus Rashford who has missed the last two games with injury and illness.
On-loan midfielder Marcel Sabitzer is unlikely to play for United again, while Lisandro Martinez, Donny van de Beek and Tom Heaton all remain sidelined.
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Chelsea have an extensive injury list, with defensive trio Ben Chilwell, Reece James and Benoit Badiashile out of action.
Mason Mount, Armando Broja, N'Golo Kante and Mateo Kovacic don't have fixed return dates either but Marc Cucurella is set to be back.
Man United vs Chelsea: What has been said?
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Ten Hag: "I think he keeps surprising us, Casemiro, he's such a brilliant football player, he's just a great football player.
"We know him for very good organisation positioning, anticipating, intercepting a lot of balls, winning duels, fighting and keeping the team together. But also in possession, his distribution and also his finishing, just a great football player.
"It was a fantastic goal from Casemiro, a brilliant finish. I was nervous at 1-0 because you can easily make a mistake and concede a goal. We had to win the game.
"We are nearly there - in the top four - but we are not there. We need a win."
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Man United vs Chelsea: Match facts
Anthony Martial has been involved in five goals in his last four starts against Chelsea (4 goals, 1 assist) although his last Premier League start against the Blues came back in February 2020 at Stamford Bridge, netting the opener in a 2-0 win for the Red Devils.
Man Utd's David De Gea has won this season's Premier League Golden Glove award, keeping 17 clean sheets; only in 2017-18 (18) has he recorded more in a single top-flight league campaign in his career. He has won the 2022-23 Golden Glove despite conceding 41 Premier League goals this season; since the award was introduced in 2004-05, this is the joint-most conceded by a Golden Glove winning goalkeeper in the competition, along with Wojciech Szczesny in 2013-14 (16 clean sheets, 41 goals conceded).
Since the start of last season, Chelsea have won none of their 15 Premier League games against sides starting the day above them in the table (D4 L11), losing each of their last four. They've lost 15 Premier League games this term, only losing more in 1993-94 (17 - 42 game season).
Manchester United need a point to secure a place in the top four and Champions League football next season. Erik ten Hag would be just the third Dutch manager to finish in the top four of the Premier League, with the other two also doing so in their debut campaigns (Guus Hiddink 2008-09, Louis van Gaal 2014-15).
Manchester United have kept a clean sheet in each of their last six Premier League home games, last going longer without conceding at Old Trafford in the league in March 2010 (7 games). In all competitions, the Red Devils have recorded 16 shutouts at home in 2022-23, last keeping more in 2015-16 (17).
Chelsea have lost their final away league game in three of the last five seasons, though they did win 3-0 at Leeds in their final such game last term.
Each of the last five Premier League meetings between Man Utd and Chelsea have been draws - Man Utd have never drawn six consecutive league games against an opponent, while Chelsea have only ever done so against West Brom (8 between 1921 and 1927).
Chelsea against Manchester United has finished as a draw more often than any other fixture in Premier League history (26). Each of the last five have been drawn, with only Aston Villa v West Ham (7), Birmingham v Liverpool (7) and Brighton v West Ham (6) ending level in more consecutive meetings.
Only Man City (8) and Liverpool (7) have won more Premier League away games against Man Utd than Chelsea (6), though the Blues are winless in their last nine visits to Old Trafford (D6 L3) since a 1-0 win May 2013.
Manchester United are unbeaten in their last 10 Premier League games against Chelsea (W3 D7) - they've never gone 11 without defeat against the Blues in their league history.