Pep Guardiola's side suffered a fourth successive defeat in the top flight on Sunday evening as they succumbed 2-0 at the home of leaders and rivals Liverpool.
City now sit 11 points adrift of the Merseyside giants in the Premier League table, as well as being just one point above their next opponents in fifth place as they bid to ensure that they do not drop further down the standings.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the contest with Nuno Espirito Santo's side
Rodri
Status: Out
Type of injury: Knee
Possible return date: Unknown
Man City are set to be without influential midfielder Rodri for the rest of the season after he suffered knee ligament damage in a 2-2 draw with Arsenal in September.
However, the Spaniard has since offered a positive update on hia recovery and has set a new target for when he wishes to return.
Oscar Bobb
Status: Out
Type of injury: Leg fracture
Possible return date: Unknown
Oscar Bobb sustained a fracture to a bone in his leg during a training session in August and Guardiola has revealed that the attacker is targeting a return between January and February of next year.
Mateo Kovacic
Status: Out
Type of injury: Unspecified
Possible return date: December 21 (vs. Aston Villa)
Guardiola revealed last week that Croatian midfielder Mateo Kovacic had entered the treatment room with an unspecified issue, and he is facing a race against time to be back before Christmas.
John Stones
Status: Major doubt
Type of injury: Unspecified
Possible return date: December 4 (vs. Nottingham Forest)
Since coming off at half time in the defeat to Tottenham Hotspur with an unspecified problem, Stones has missed the last two matches. As it stands, it is unclear when the defender will return.
MANCHESTER CITY'S SUSPENSION LIST
Man City have no players suspended for this match.