Pep Guardiola's side are in excellent form and will be hoping to follow up on last week's impressive result against Watford.
Bruno Lage's side are enjoying a decent campaign and find themselves in eighth position in the table.
They have, however, scored just one in their last five games and that's something that they'll be hoping to address.
Manchester City v Wolves: Date and time
The Premier League clash is due to take place on Saturday, December 11 at the Etihad Stadium in Manchester.
Kick-off is scheduled for 12.30pm.
Victory would guarantee that City end the weekend in top spot.
Manchester City v Wolves: talkSPORT commentary
The Gameday exclusive with Reshmin Chowdhury will get underway at 11am.
Commentary will then come from Nigel Adderley and former Manchester City and England winger Trevor Sinclair.
Manchester City v Wolves: Team news
Pep Guardiola should be boosted by the return of Kevin De Bruyne to top-flight action.
He could, however, be without Nathan Ake and Phil Foden who were forced off against RB Leipzig.
Gabriel Jesus and Aymeric Laporte will face late fitness tests while Ferran Torres remains out as a long-term absentee.
Wolves captain Conor Coady is a doubt with an ongoing ankle issue.
Fernando Marcal could also miss out following a positive Covid-19 test.
Manchester City v Wolves: Match facts
Manchester City have lost just one of their last nine home games against Wolves in all competitions (W6 D2), going down 2-0 in October 2019.
Having done the league double over Manchester City in 2019-20, Wolves lost both Premier League meetings with the Citizens last season by an aggregate score of 7-2.
Among all fixtures to have been played at least 60 times in the history of the English Football League since it was formed in 1888, Man City vs Wolves has the highest goals-per-game ratio of 3.83 (437 goals in 114 meetings).
Manchester City have won 31 of their 39 Premier League games in 2021 (D2 L6) - only Liverpool in 1982 (33) and Chelsea in 2005 (32) have won more matches in a single calendar year in English top-flight history.
Wolves have lost 20 of their last 23 away top-flight matches against the reigning champions (W3) but did win 2-0 at Man City in the 2019-20 campaign.
Excluding penalties, Wolves are the only side that are yet to concede a set piece goal in the Premier League this season, despite facing 39 shots from such situations. By contrast, only Leeds (15) conceded more set piece goals (excl. pens) in the Premier League last season than Wolves (14).
Man City forward Gabriel Jesus has scored in all three of his Premier League starts against Wolves, netting five goals in total. The Brazilian has only scored more against Everton in the competition (8) than he has against Wolves.
Wolves' Adama Traoré has scored more Premier League goals against Man City than he has against any other side (3), netting both goals in Wolves' only away Premier League victory against the Citizens in October 2019.
Raheem Sterling has scored 99 Premier League goals (18 for Liverpool, 81 for Manchester City). He would be the 32nd different player to reach triple figures in the competition, and the eighth youngest to do so (27 years and 3 days on the day of this game).
Bernardo Silva has scored six goals in his last eight Premier League appearances for Manchester City - one more than in his previous 61 games in the competition (5) and is the top scoring midfielder in the Premier League so far this term (7).