Pep Guardiola's side smashed the Portuguese outfit 5-0 away during the first leg last month as they seek a first European triumph at the Etihad.
Bernardo Silva scored twice along with goals from Raheem Sterling, Riyad Mahrez and Phil Foden to effectively kill the tie before the return fixture.
Sporting have a mountain to climb as no team has ever come back from a five-goal first-leg deficit to advance in the Champions League.
Manchester City v Sporting Lisbon: Date and time
This Champions League clash will take place on Wednesday, March 9.
The last-16 second leg at the Etihad will kick-off at 8pm.
City warmed up for the return game with a convincing 4-1 win over rivals Man United in Sunday's derby and now have the chance to rotate their squad.
Manchester City v Sporting Lisbon: Live stream and TV Channel
This match will be broadcast live on BT Sport 2 with live coverage starting from 7pm.
BT Sport customers can live stream this via the app using their mobile, tablet or computer devices.
To tune in to talkSPORT or talkSPORT 2, click HERE for the live stream.
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Manchester City v Sporting Lisbon: Team news
The hosts will continue to be without Ruben Dias due to injury and Nathan Ake will not recover from a knock in time to feature.
Cole Palmer and Zack Steffen are both nursing issues as well, while Joao Cancelo is ill meaning Oleksandr Zinchenko can expect to play.
Kyle Walker is still serving the second of his three-game European ban and Kevin de Bruyne is one booking away from suspension.
Sporting, meanwhile, are missing Matheus Nunes through his own ban, while Joao Palhinha and Pedro Goncalves are both out injured.