The festive schedule is upon us and that means Premier League matches come thick and fast.
The Blues sealed a hugely fortuitous 2-1 victory over Watford at Vicarage Road on Wednesday in a match where the European champions were dominated for large parts of the encounter.
Goals from Mason Mount and Hakim Ziyech ultimately got the job done for the Premier League leaders, who sit just one point ahead of Manchester City at the top-flight summit after 14 games.
But what is the latest Chelsea team news how could they line-up for the clash at the London Stadium?
Tuchel provided a positive injury update in his press conference on Friday, but there are still some big name absentees from his squad.
He hailed the 'massive' boost of Reece James and Jorginho's return to fitness for Saturday's Premier League trip to Stratford.
James missed the Watford win with an ankle injury, while Italy midfielder Jorginho was not fit enough to start.
However, the Blues are still without sidelined quartet Trevoh Chalobah, Mateo Kovacic, N'Golo Kante and Ben Chilwell for the east London trip, with the Blues in the grip of an injury glut.
James and Jorginho will ease shortages at wing-back and in midfield, however, leaving boss Tuchel delighted to have two senior, in-form stars back in action.
"Reece James and Jorginho are both available again," said Tuchel.
"It's massive, because Reece is the specialist on the right, and Jorgi is the guy left from Mateo Kovacic, N'Golo Kante and him from the three on whose shoulders we put the central role over a very long period now.
"I'm absolutely happy that Ruben Loftus-Cheek steps in in the way he does it, but we are happy that Jorgi is back in training.
"And we can't wait for Kova and NG to come back because it is a very important part, not only of the season but also in our games, and this midfield role, where we miss the experience and the leadership qualities of the guys who are out. So it's good that they are back.
"But listen: we will never complain, because we are here to find solutions, and if we miss players, other players will play.
"They have contracts here because they deserve them.
"This is what we do, and we'll have a strong team on the pitch tomorrow.
"We had a strong team against Watford, we are used to having changes in between and this is where we go."
Chelsea's potential line-up vs West Ham
With Chilwell out, Alonso is likely to keep his place at left-back, though Callum Hudson-Odoi could also play in that position according to Tuchel.
James will return straight to the starting XI looking to continue his electric start to the season, having scored four goals and added the same amount of assists in ten matches this term.
Ruben Loftus-Cheek will keep his place in the middle of the park, with Saul - a huge disappointment against Watford - dropped for Jorginho from the XI.
Kai Havertz was impressive at Vicarage Road and he will start out on the left, with Mount occupying the opposite flank.
Lukaku's long-awaited return to the starting XI will provide a much needed boost for Tuchel.
Chelsea fans will be hoping the £97.5m man can kick on this season with a flurry of goals now.