The Reds are already in the final of one domestic trophy - the Carabao Cup against Chelsea - but have never won either competition under Jurgen Klopp.
Liverpool boss Klopp rotated his squad during the FA Cup third round win over League One Shrewsbury Town and may do so again this weekend.
Championship outfit Cardiff are 20th in the table and beat Preston North End 2-1 to earn their fourth-round spot.
Liverpool v Cardiff: talkSPORT coverage
This FA Cup tie will kick-off at 12pm on Sunday, February 6.
Adrian Durham will be your host and commentary will come from Nigel Adderley and former England defender Micky Gray.
talkSPORT.com will also be running a live blog for all the action and you can get all the latest news on the talkSPORT app as well.
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Liverpool v Cardiff: Team news
Liverpool
The hosts remain without star attackers Mohamed Salah and Sadio Mane due to their involvement in the Africa Cup of Nations.
However, Naby Keita is back with the rest of his teammates following Guinea's exit in the tournament and could be involved.
Luis Diaz could make his debut following his big-money move from Porto while Thiago Alcantara is in line to make his return from injury.
Harvey Elliott may even be afforded some minutes having played in a behind-closed-doors U23s match against Wrexham at Kirkby on Saturday.
Cardiff City
The hosts are without striker Kieffer Moore, 29, after the Welshman sealed a deadline day switch to Bournemouth.
Cardiff brought in Middlesbrough forward Uche Ikpeazu on loan for the rest of the season as Moore's replacement.
And the 26-year-old scored the winner on his debut after emerging as a substitute in the 1-0 away win over Barnsley on Wednesday.
Elsewhere, Cardiff have reported a clean bill of health other than long-term absentee Isaac Vassell.
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