The Reds are already in the final of one domestic trophy - the Carabao Cup against Chelsea - but have never won either competition under Jurgen Klopp.
Liverpool boss Klopp rotated his squad during the FA Cup third round win over League One Shrewsbury Town and may do so again this weekend.
Championship outfit Cardiff are 20th in the table and beat Preston North End 2-1 to earn their fourth-round spot.
FA Cup clash to kick-off at Anfield at 12pm
Contest will be live on talkSPORT with Adrian Durham, with commentary coming from Nigel Adderley and Micky Gray
Liverpool: Kelleher, Alexander-Arnold, Konate, Van Dijk, Tsimikas, Henderson, Keita, Jones, Minamino, Jota, Firmino
Subs: Adrian, Thiago, Milner, Diaz, Robertson, Matip, Gordon, Elliott, Morton
Cardiff: Phillips, Ng, McGuinness, Flint, Denham, Bagan, Vaulks, King, Pack, Harris, Collins
Subs: Smithies, Bacuna, Hugill, Wintle, Doyle, Colwill, Semenyo, Bowen, Davies
talkSPORT will have updates throughout the day and you can listen through our radio player below
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