Sadio Mane, Mohamed Salah and Roberto Firmino are all on the bench as the Reds welcome Danish side FC Midtjylland to Anfield in the Champions League on Tuesday night.
In place of the star forwards, Klopp has given Divock Origi, Takumi Minamino and Xherdan Shaqiri rare starts.
The other change sees James Milner comes in for Georginio Wijnaldum, while Diogo Jota, who scored the winner against the Blades, keeps his place in the team.
Midfielder Fabinho plays alongside Joe Gomez for a third straight match with Virgil van Dijk a long-term absentee.
Below you can see the full Liverpool team news.
Liverpool: Alisson, Alexander-Arnold, Fabinho, Gomez, Robertson, Henderson, Milner, Shaqiri, Jota, Minamino, Origi
Subs: Kelleher, Adrian, Wijnaldum, Firmino, Cain, Mane, Salah, Jones, Rhys Williams, Neco Williams
FC Midtjylland: Andersen, Andersson, Sviatchenko, Scholz, Paulinho, Onyeka, Cajuste, Dreyer, Sisto, Mabil, Kaba Subs: Cools, Evander, Kraev, James, Vibe, Ottesen, Pfeiffer, Anderson, Madsen, Dyhr, Isaksen, Thorsen
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The six-time winners of the competition got off to a good start in this season's campaign as they got the better of Ajax, winning 1-0 at the Amsterdam ArenA.
A win tonight could put Liverpool in charge of their group, with Ajax travelling to Atalanta, who beat Midtjylland 4-0 on matchday one, tonight.
Jurgen Klopp has made FOUR changes to the Liverpool side that beat Sheffield United last weekend, most notably leaving his dangerous front three out of the starting XI.