Jurgen Klopp will ring the changes when Liverpool go to Norwich City in the Carabao Cup on Tuesday evening.
The Reds head to Carrow Road for what is already the second time this season having won there 3-0 on the opening weekend of the Premier League campaign, when Diogo Jota, Roberto Firmino and Mo Salah all found the net.
This time around, Firmino is one of four players who have been ruled out of the match by Reds assistant boss Pep Lijnders, with the Brazilian still absent with a hamstring issue.
Firmino is set to return to Liverpool training this week though, and is likely to be involved in Saturday's Premier League trip to Brentford.
Thiago Alcantara, Trent Alexander-Arnold and Alexander-Arnold's right-back understudy Neco Williams are also absent, with the Spanish midfielder limping off in the 3-0 win over Crystal Palace at the weekend, a match which Alexander-Arnold missed through illness..
Thiago suffered a calf injury in the win over Palace ( Image:
PA)
The former Barcelona and Bayern Munich man is also expected to miss the Brentford trip, although Alexander-Arnold should return.
"Thiago, how the gaffer said after the game, it was a calf injury. I can't say now how long it will take but definitely not tomorrow and not at the weekend," said Lijnders on Monday.
"Trent, there are no symptoms - no Covid symptoms.
"We test regardless. He should be fine in a few days but Norwich comes too early.
"Then we have Bobby, who will do parts of team training but also not ready. But progressing well. And Neco is progressing well as well. [For him] tomorrow also comes too early."
Lijnders has already confirmed two of Liverpool's starting XI, with goalkeeper Caoimhin Kelleher taking his usual spot in this competition, and midfielder Curtis Jones making his 50th appearance for the club after appearing from the bench in the last two matches.
The absences of Alexander-Arnold and Williams mean that Joe Gomez could come into the side at right-back, allowing for Nat Phillips to make his first appearance of the season in the centre and Ibrahima Konate and Kostas Tsimikas to hold onto their places from the weekend.
How Liverpool could look for the Carabao Cup clash
Thiago's absence and likely rests for Fabinho, Jordan Henderson and James Milner could mean that Naby Keita plays in the centre of midfield along with Jones and Alex Oxlade-Chamberlain..
With the usual forwards rested, we could see an attack made up of Takumi Minamino,Divock Origi and teenager Kaide Gordon, who is pressing to make his senior debut and was praised by Lijnders on Monday.
"About Kaide, I called Jurgen immediately and was like, 'wow! We have a new player here," said Lijnders as he recalled watching Gordon in the summer.
"Before pre-season we always make sure our biggest talents start a week earlier than we start. They start with the U23s so I went to the Unde r23s training ground, watching.
"And I saw one player and he has fire in each moment that he touches the ball. He passes players like they are not there."