The Citizens head into the weekend in second position in the WSL table, while the Reds are currently sitting in fourth position.
Match preview
Liverpool have built upon last season's seventh-place finish, picking up 29 points from 17 matches to move into fourth spot with five games left to play.
Despite enjoying an impressive campaign, Liverpool may have been slightly disappointed to play out a 0-0 draw in last Sunday's Merseyside derby against Everton.
Although the Reds had to settle for a point, the goalless affair extended their unbeaten run to five league matches (W3, D2).
The Merseyside club have proven to be a tough team to beat on home turf, having lost just one of their last six WSL games.
The Reds will certainly have their work cut out to pick up a positive result against the Citizens, with their last 10 matches producing one win and nine defeats.
Man City are firmly in the hunt to win their second WSL title after winning 14, drawing one and losing two of their 17 matches.
The Citizens claimed their most recent victory in last Sunday's game against rivals Manchester United, with Jess Park netting a brace before Bunny Shaw found the net to wrap up a 3-1 home win.
Having won each of their last 11 league matches, Gareth Taylor's side are currently sitting second place and level on 40 points with leaders Chelsea.
With Chelsea set to face Arsenal in the League Cup final this weekend, Man City have the chance to move into pole position and pile the pressure on their title rivals.
The Citizens have already beaten Liverpool on two occasions this season, winning 4-3 in November's League Cup tie before recording a 5-1 victory in January's WSL meeting.
Liverpool Women Women's Super League form:
L
D
W
W
W
D
Liverpool Women form (all competitions):
Manchester City Women Women's Super League form:
W
W
W
W
W
W
Manchester City Women form (all competitions):
Team News
Liverpool are unable to call upon Niamh Fahey and Jasmine Matthews, who are sidelined with calf and hamstring issues respectively.
Shanice van de Sanden has been ruled out with an ankle problem, while Yana Daniels is unavailable due to a concussion.
Matt Beard has confirmed Finland international Emma Koivisto will be available for selection after missing the Merseyside derby through injury.
Taylor Hinds is also set to return to action, but the 24-year-old will only be ready to take up a place on the bench.
As for the visitors, defender Laia Aleixandri is unlikely to feature after she pulled out of the warm-up in the Manchester derby due to an injury problem.
The title challengers remain without the services of midfielder Jill Roord, who is working on her rehabilitation from an anterior cruciate ligament injury.
After seeing his side claim a 3-1 victory last weekend, Taylor is set to name an unchanged lineup for Saturday's Prenton Park.
Liverpool Women possible starting lineup:
Laws; Clark, Fahey, Fisk, Koivisto, Nagano, Nagano, Holland, Parry; Kearns, Haug, Kiernan
Manchester City Women possible starting lineup:
Keating; Casparij, Kennedy, Greenwood, Ouahabi; Park, Hasegawa, Coombs; Fowler, Hemp, Shaw
We say: Liverpool Women 1-2 Manchester City Women
Having avoided defeat in their last five league games, Liverpool should provide Man City with a tough test at Prenton Park.
Manchester City 
Everton 
Chelsea 
Fulham 
Nottingham Forest 
Tottenham 
Celtic 
Motherwell 
Wolverhampton 
Manchester Utd 
ST Mirren 
Rangers 
Sampdoria 
Carrarese 
Liverpool 
Leicester 
Arsenal 
Ipswich 
Cagliari 
Inter 
Lazio 
Atalanta 
FC Porto 
Boavista 
Udinese 
Torino 
Napoli 
Venezia 
ST Johnstone 
Juventus 
Fiorentina 
West Ham 
Pisa 
AC Milan 
Roma 
Sporting CP 
Benfica 
Newcastle 
Brentford 
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