The Foxes are going well in the knockout stages of the inaugural season of the Europa Conference League.
Brendan Rodgers' side smashed Randers in their play-off clash before edging past Rennes in the Round of 16.
They are now ready for their toughest test so far and will be eager to claim a first-leg advantage against PSV.
Roger Schmidt's Boerens, who are second in the Dutch Eredivisie table, have beaten Maccabi Tel Aviv and Copenhagen to reach this stage.
Leicester v PSV: Date and start time
This Europa Conference League clash will take place on Thursday, April 7.
The game at the King Power is scheduled to kick off at 8pm UK time.
This will be the first competitive meeting between the two sides.
Leicester v PSV: TV channel and live stream
This match will be broadcast on BT Sport 3 with coverage starting at 7:15pm
BT Sport customers can live stream this via the app using their mobile, tablet or computer devices.
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Leicester v PSV: Team news
Jamie Vardy remains out for Leicester.
The striker is sidelined with a knee injury, while Danny Ward, Ryan Bertrand and Wilfred Ndidi are also out with knee issues.
Brendan Rodgers said: "It is hard to put a timeline on it. He is still feeling pain within the knee. He can run and he is outside, but when he is striking the ball there is an issue so we will have to get to the bottom of that.
"I just spoke to Jamie. He had been outside, running in straight lines. It was just when he was opening up the MCL a bit when he is striking the ball that he was getting some pain in that.
"I will have to speak to the medical team to see where that is at, but it doesn't sound as if he is too close to being back."
Luke Thomas could play a role for the Foxes while the likes of James Justin, Timothy Castagne, Wesley Fofana and Jonny Evans have returned from injury in recent weeks.
Leicester v PSV: What has been said?
Leicester defender Wesley Fofana: "It's a big game and they are a great side.
"They've done well in the Champions League and Europa League in the past. They're a talented side, with good players, so it will be a very difficult game, but we are a good side and will do everything we can to win the game.
"If we win the first game, we go to them with a lot more confidence, because we will have an advantage over them.
"However, both games are important, as we went into the game at Rennes 2-0 up, and the return leg was very close, so it's important we don't take our foot off the gas.
"It's always better to win the first leg as it gives you that advantage.
"I'm so excited to be back. I can't wait to be back at the stadium playing in front of our fans, as last season we had COVID so I didn't get that opportunity.
"I'm a little nervous, but I'm also excited and can't wait to get out there."