The Gunners leapfrogged West Ham into fourth with a 2-0 win over their London rivals on Wednesday night.
Leeds, meanwhile, were hammered 7-0 at Manchester City in midweek and are just five points clear of the relegation zone.
The teams below them have games in hand amid the raft of matches called off due to Covid and Marcelo Bielsa's men are in desperate need of points.
Arsenal beat Leeds in the Carabao Cup in October, claiming a 2-0 victory.
Leeds v Arsenal: talkSPORT commentary
This Premier League clash will take place on Saturday, December 18.
It will be held at Elland Road and will kick off at 5:30pm.
This game will be live and exclusive on talkSPORT with coverage starting at 5pm.
Lynsey Hipgrave will be your host and commentary will come from Clive Tyldesley and former England defender Micky Gray.
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Leeds v Arsenal: Team news
Daniel James is out with a muscle problem and joins Kalvin Phillips, Liam Cooper, Jamie Shackleton, Pascal Struijk, Rodrigo and Patrick Bamford on the sidelines.
Junior Firpo is suspended after picking up his fifth yellow card last time out.
Arsenal have a clean bill of health on the injury front.
Pierre-Emerick Aubameyang, who was stripped of the captaincy for disciplinary reasons earlier this week, will not be available for selection again.
Sead Kolasinac remains a long-term absentee.
Leeds v Arsenal: Match facts
Leeds United are winless in their last 10 meetings with Arsenal in all competitions (D2 L8) since a 3-2 victory at Highbury in May 2003.
Arsenal are unbeaten in their last six away games against Leeds in all competitions (W4 D2) since a 1-0 loss in November 2000. Meanwhile, the Gunners haven't conceded more than once in any of their last 13 trips to Elland Road, since a 2-1 loss exactly 28 years ago today (18th December 1993).
Arsenal have won 10 of their last 13 away league games against Yorkshire sides (D1 L2), with both defeats in that run coming against Sheffield United. It's more victories than the Gunners had managed in their previous 49 league visits to the county (W9 D17 L23).
Leeds are unbeaten in their last five home league games (W2 D3), having picked up just one point from their first three at Elland Road this season (D1 L2).
Arsenal have lost their last three away league games, conceding more goals in this run (9) than they had in their previous nine on the road combined (8). The Gunners last lost more consecutive away league games between January and May 2018 under Arsène Wenger (7).
Leeds have lost their last two Premier League games, conceding as many goals in these defeats (10) as they had in their previous 10 league games combined. The Whites haven't lost three consecutive games in the top-flight since April/May 2004, a run that included a 5-0 loss against Arsenal.
Since Mikel Arteta's first game in charge on Boxing Day in 2019, Arsenal have scored 28 Premier League goals via players aged 21 or younger - more than any other team.
Since the start of last season, Leeds United average 1.6 goals-per-game when Patrick Bamford plays, compared to just 0.9 when he's absent. The Whites have won 41% of their Premier League games with Bamford in the side (18/44), and just 27% without him (3/11).
Englishmen Calum Chambers and Eddie Nketiah scored for Arsenal in their 2-0 win against Leeds in the EFL Cup earlier this season. Before this, just one of the Gunners' last 35 goals against the Whites in all competitions had been scored by an English player.
Arsenal pair Emile Smith Rowe (21) and Bukayo Saka (20) have assisted one another six times in the Premier League; among duos when both aged 21 or younger, only Cristiano Ronaldo and Wayne Rooney (8) have assisted one another more often in the competition's history.