The visitors head for Stadio Via del Mare on the back of a long winless run, while their hosts' recent revival was quelled last weekend.
Match preview
Having previously pulled level on points with last week's opponents Roma, after the arrival of new coach Marco Giampaolo brought about an uptick in fortunes, Lecce were still in contention to surpass their hosts at half time.
A penalty converted by Nikola Krstovic sent them down the tunnel all square at 1-1, but the Salentini's second-half collapse then saw Claudio Ranieri's men run out 4-1 winners at Stadio Olimpico.
Responding to a change of management, Lecce had finally posted their first away win at Venezia, then snatched a last-gasp point at home to Juventus, but that brief unbeaten streak was swiftly ended in the Eternal City.
Still heavily reliant on Krstovic - who has scored as many times in one UEFA Nations League match with Montenegro as for his club this season - the Giallorossi have registered the fewest different scorers in Serie A: only four so far.
They will therefore be keen to step up a gear against one of the few teams below them in the table, having previously gone undefeated through four top-flight meetings with Monza to date.
The pair played out a 1-1 draw in their last encounter, April's league clash at Via del Mare, when Krstovic scored what seemed to be a winner in the 92nd minute, before Monza skipper Matteo Pessina dramatically struck back from the spot.
Looking up at 16th-placed Lecce, Monza are mired in the Serie A drop zone ahead of Sunday's game, with just 10 points on the board so far.
That meagre tally is less than half of the 21 they had collected by this stage last season, representing the largest such deficit of any team in the Italian top flight.
Alessandro Nesta's men are winless in seven matches after suffering a 2-1 home defeat to Udinese on Monday, leaving them in 19th place approaching the halfway point of their 2024-25 campaign.
The Brianzoli have not tasted success since October and were also knocked out of the Coppa Italia last week, so a lengthy survival fight now looms for a club that secured safe mid-table finishes in both seasons since their historic promotion.
There is a glimmer of hope for Monza fans this week, though, as they have picked up 70% of their points on the road - the highest share throughout Serie A.
Lecce Serie A form:
W
L
D
W
D
L
Monza Serie A form:
L
L
L
D
D
L
Monza form (all competitions):
L
L
D
D
L
L
Team News
Lecce will be without two members of their regular back four this weekend, as Kialonda Gaspar has joined Antonino Gallo on the sidelines due to injury; Lameck Banda, Kevin Bonifazi and Filip Marchwinski are also ruled out.
Andy Pelmard - a possible defensive replacement - has been laid low by illness and is therefore a doubt, but in better news for Marco Giampaolo, midfielder Balthazar Pierret has returned to full training.
Leading the hosts' attack, Nikola Krstovic scored in both games against Monza last season, while Ante Rebic and Patrick Dorgu should provide his supply from out wide.
Meanwhile, Monza's main threat may not come from veteran striker Milan Djuric but Greek wing-back Georgios Kyriakopoulos, whose recent strike against Udinese took him on to five goal involvements for the season - that already equals his best Serie A tally.
Dany Mota and Daniel Maldini are set to support Djuric in the final third, though the claims of Gianluca Caprari cannot be counted out.
Once again, the Biancorossi are without injured goalkeeper Alessio Cragno, and midfield duo Roberto Gagliardini and Matteo Pessina - the latter pair's fitness issues have accelerated a potential loan move for Chelsea's Cesare Casadei.
Lecce possible starting lineup:
Falcone; Guilbert, Baschirotto, Jean, Pelmard; Coulibaly, Rafia, Ramadani; Rebic, Krstovic, Dorgu
Monza possible starting lineup:
Turati; Izzo, Mari, Carboni; Birindelli, Bianco, Bondo, Kyriakopoulos; Maldini, Mota; Djuric
We say: Lecce 1-2 Monza
Crosses and set-pieces could play a part in this game's outcome, as Monza have conceded the most headed goals in Serie A (eight), with Lecce lying joint-second (six) in those rankings.
Written by
Jonathan O'Shea