With the Premier League title already in the bag, Liverpool won't want to say goodbye for their Champions League chances on Wednesday night.
Jurgen Klopp's side will have to come from a goal down to progress past Atletico Madrid at Anfield.
The good news for the hosts is that Jordan Henderson is fit and is expected to start in midfield alongside Fabinho and Georginio Wijnaldum.
Those three will come up against the physicality of Thomas Partey, Koke and Saul in the middle of the park.
At full-back, Kieran Trippier and Renan Lodi will have to sacrifice a bit of their attacking instincts to deal with the threat of Trent Alexander-Arnold and Andy Robertson. Not to mention Sadio Mane, Mohamed Salah and Roberto Firmino.
Diego Simeone will look to unsettle the Liverpool backline with the likes of Angel Correa, Alvaro Morata and Joao Felix, with Klopp relying on Virgil van Dijk to lead the defensive duties against them.
The absence of the injured Alisson will be an important factor, with Adrian charged to filling the Brazilian's boots in between the sticks.
Off the pitch, the famous Anfield atmosphere will play a crucial part if Liverpool are to mount another Champions League comeback.
All of Klopp's eight defeats as Liverpool boss in the competition have come away from home while the Reds have won 19 of their last 21 home games in all competitions.