Neither side has made a good start to the season but there's no doubt Liverpool are in a better position as a club than the Red Devils.
And Reds boss Jurgen Klopp couldn't resist having a cheeky dig at Man United ahead of the match by suggesting his club had saved a fortune by not having to pay off as many managers as their arch-rivals in recent years.
Since the German arrived in 2015 half a dozen people - either permanent or interim - have taken charge at Old Trafford.
Klopp suggested it must have been a costly exercise.
"Imagine the money Liverpool saved from not paying them (a similar number of managers) off," said the Reds boss ahead of Monday's meeting.
"I should have said that when I signed the last contract. It would have been an interesting number."
The stats don't look great for Man United, who will be looking to avoid a number of unwanted feats against Liverpool.
Liverpool are looking to win four consecutive league games against Manchester United for the first time since January 2002, and are looking to win three straight away league games against them for the first time in their history.
A defeat for Man United will see them first three league games for only the fourth time in their history, the last coming in the 1986/87 season. Erik ten Hag would become just the second Red Devils manager to lose each of his first three matches in charge of the club since John Chapman in 1921.
Losing to Liverpool would also consign them to a fifth league defeat in a row, which they haven't managed since March 1972.
And a goal for Mohamed Salah will make him become the first Liverpool player in the club's history to reach double figures against Man United.
Things are chaotic on and off the pitch at Old Trafford and although talkSPORT's Tony Cascarino believes Man United will one day come back, it won't be any time soon.
Cascarino said on Weekend Sports Breakfast: "United as a football club will come back. They will have new owners one day and it will be different - just not at present.
"It feels like this club is run so badly that every area of the football club is going backwards.
"I don't work at the club or Carrington training ground but all I see is failure on every level. I don't even get a vibe of an exciting youth team or young players who are coming through.
"It seems like everyone that's joining that football club is signing massive deals."
But for those 90+ minutes come 8pm on Monday, all these problems will be away from the minds of the Man United players as their sole focus is on getting the points and bragging rights against their oldest foes.