Kidderminster pulled off a brilliant 2-1 win over Reading earlier this month to reach the fourth round of the historic cup.
Russell Penn's Kiddy, who are third in the National League North table, will be looking to pull off one of the biggest shocks in recent memory when they take on West Ham.
The Hammers beat Leeds in the last round and are still challenging for Champions League football in the top-flight.
talkSPORT will be in Worcestershire to bring you full coverage of this intriguing David v Goliath cup tie.
Kidderminster v West Ham: talkSPORT coverage
This FA Cup tie will kick-off at 12:30pm on Saturday, February 5.
Adrian Durham will be your host and commentary will come from Sam Matterface and former Hammers defender Alvin Martin
talkSPORT.com will also be running a live blog for all the action and you can get all the latest news on the talkSPORT app as well.
To tune in to talkSPORT or talkSPORT 2, click HERE for the live stream.
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Kidderminster v West Ham: Team news
Nathan Cameron and Joe Foulkes have been back in training for Kidderminster and could start.
Keziah Martin and Ethan Freemantle have also recently returned from injury but this tie will likely come too soon for both.
Harriers will be without Marcus Dinanga after he was recalled by parent club Altrincham.
Lukasz Fabianski is still nursing a knock and will likely be left out again with Alphonse Areola deputising.
Angelo Ogbonna is a long-term injury absentee with a knee problem.
The Hammers will likely make changes with Mark Noble, Alex Kral, Andriy Yarmolenko and Ryan Fredericks set to start.
Kidderminster v West Ham: What has been said?
Kidderminster manager Penn is dreaming of history as his side prepare to host West Ham.
Penn said: "I said to the lads in the changing room after we beat Leamington that we have to believe history can be made one day, so let's hope it could be Saturday. We've given ourselves an opportunity to do that.
"We are in an empty book to be scripted and we will give it our best shot.
"I knew about the David Moyes link, but I completely forgot about Gold and Sullivan. This is what I mean, it is history.
"How many years ago are we talking? Twenty-eight years. It is unbelievable and these people are still in the game, which is why I have the utmost respect for David Moyes.
"What a manager to come to the place. I know he will respect us, respect the football club and respect the competition with the team he will put out."