David Moyes' side have enjoyed an excellent start to their season and come into this contest full of confidence following a 3-0 victory over Genk in the Europa League on Thursday night.
For Spurs this will be a chance to get themselves back on track after their shock defeat to Vitesse Arnhem in the Europa Conference League.
With just a point separating the two teams in the Premier League it could be a tight contest, but on past encounters they certainly haven't lacked entertainment.
West Ham v Tottenham: Date and kick-off time
The Premier League clash will take place on Sunday, October 24.
It will be played at the London Stadium, Stratford, the home of West Ham United.
Kick-off is set for 2pm UK time.
West Ham v Tottenham: How to watch
The clash will be live on Sky Sports Main Event and Sky Sports Premier League.
Coverage will begin at 1pm and Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
If not, you can purchase a Sky Sports Day Pass from NowTV for £9.99.
West Ham v Tottenham: Team news
West Ham XI | Fabianski, Johnson, Ogbonna, Zouma, Cresswell, Rice, Soucek, Bowen, Benrahma, Fornals, Antonio
Subs | Areola, Dawson, Diop, Masuaku, Ashby, Noble, Lanzini, Vlasic, Yarmolenko
Tottenham XI | Lloris, Royal, Romero, Dier, Reguilon, Hojbjerg, Skipp, Ndombele, Lucas, Son, Kane
Subs | Gollini, Sanchez, Tanganga, Rodon, Davies, Dele, Lo Celso, Bergwijn, Bryan
West Ham v Tottenham: Match facts
West Ham avoided defeat in both Premier League meetings with Spurs last season (W1 D1) - they haven't gone three league games without defeat against their London rivals since May 2006.
Tottenham have won three of their last four visits to the London Stadium to face West Ham in the Premier League, though they did lose this exact fixture 2-1 last season.
Tottenham have lost each of their last four Premier League London derbies, as many as they had in their previous 17 such games combined (W7 D6). Spurs haven't lost more consecutive league derbies since a run of six between March 2003 and January 2004.
West Ham have lost their last two home league games, both by a 2-1 scoreline and thanks to winners in the 89th minute (vs Man Utd) and 90th minute (vs Brentford). They've not lost three consecutively at home in the competition since a run of four under Manuel Pellegrini in December 2019 - his final four such games at the club.
None of Tottenham's last 14 Premier League games have ended level (W9 L5), their longest run without a draw in the competition since a run of 32 between April 2018 and February 2019.
No side has used fewer different players in the Premier League this season than West Ham (18), with David Moyes' Hammers also making a league-low four changes to their starting lineups this term.
Tottenham's Harry Kane has only scored more Premier League goals against Leicester (15) than he has against West Ham (11), although only three of those have come away from home.
West Ham's Michail Antonio has scored more Premier League goals against Spurs than he has versus any other side (5). Three of these goals have been scored in one-goal victories (and have been worth six points to the Hammers), while the other two were scored in 3-2 defeats.
Son Heung-min's goals (4) and assists (1) have been worth eight points to Tottenham in the Premier League this season, more than any other player in the competition so far this term.
West Ham pair Saïd Benrahma and Michail Antonio have created 17 chances for each other in the Premier League this season, more than any other duo in the competition.