The 18-year-old secured a high-profile move to the Lilywhites from Leeds United last month, with the youngster playing predominantly as a right-back for Daniel Farke's side.
However, Gray started alongside Emerson Royal at centre-back for Spurs' 3-2 win over J1 League outfit Vissel Kobe as Ange Postecoglou's side commenced their tour of Asian.
Finding the net last time out, Pedro Porro is expected to maintain his spot at right-back, whilst veteran Ben Davies will hold down the fort at left-back.
After an injury scare at Queens Park Rangers earlier this month, Lucas Bergvall featured in the win over Vissel Kobe as a substitute and the Swede could receive a cameo off the bench once again.
At just 16 years of age, Mikey Moore is taking a real impression at senior level for Spurs so far in pre-season and could start up front at the expense of Dejan Kulusevski.
Both only playing for 45 minutes last time out, James Maddison and Yves Bissouma are expected to start as the Lilywhites come up against the best that the K-League have to offer on Wednesday.
Tottenham Hotspur possible starting lineup: Vicario; Porro, Royal, Gray, Davies; Sarr, Bissouma, Johnson, Maddison, Son; Kulusevski
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Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
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