It means the champions have one centre-back on show for Burnley's visit, having had to use Jordan Henderson and Fabinho in that slot during their last two Premier League matches.
Fabinho lines up alongside Matip, however, Henderson will play no part in the Anfield clash.
The Liverpool captain is out with a minor groin strain, meaning Alex Oxlade-Chamberlain joins Thiago Alcantara and Georginio Wijnaldum in midfield.
Jurgen Klopp has made some surprise decisions up front with Mohamed Salah and Roberto Firmino both on the bench. Xherdan Shaqiri and Divock Origi are in attack alongside Sadio Mane.
Burnley made two changes, with left-back Charlie Taylor returning after a hamstring injury and Dwight McNeil starting as Erik Pieters and Johan Berg Gudmundsson missed out.
Below you can see how both sides line up.
Liverpool: Alisson, Alexander-Arnold, Matip, Fabinho, Robertson, Oxlade-Chamberlain, Thiago, Wijnaldum, Shaqiri, Mane, Origi
Subs: Milner, Firmino, Salah, Jones, Minamino, Tsimikas, Phillips, Kelleher, Neco Williams
Burnley: Pope, Lowton, Tarkowski, Mee, Taylor, Brady, Westwood, Brownhill, McNeil, Wood, Barnes
Subs: Cork, Gudmundsson, Peacock-Farrell, Stephens, Rodriguez, Pieters, Bardsley, Vydra, Long
Joel Matip returns to the Liverpool squad and has been given a starting spot for their Premier League clash against Burnley.