While it was good news on the pitch for Man City, with a 3-1 win giving them a huge advantage on the night, they have been hit with a number of potential injury setbacks.
Bernardo Silva and Phil Foden got the goals to hand City a two-goal lead heading into next month's second leg, after Kevin De Bruyne's opener had been cancelled out by Magnus Mattsson.
Silva is one of the players who could be set for a spell on the sidelines though, after he limped off late on with a suspected ankle problem.
Speaking to the press after the match, Guardiola revealed that Silva suffered a "big knock in his ankle".
That came after Jack Grealish had already been forced off in the first half, following an off-the-ball incident shortly after the opening goal.
Guardiola said: "I did not speak with the doctor but it looks muscular. It's a pity, in the last days his attitude in training was much much better. He helps us find the right tempo."
It was Grealish's first start since their 5-0 win over Huddersfield Town at the start of January, but was cut short inside just 20 minutes, as despite his best efforts, he could not continue.
The 28-year-old has played just 18 minutes since that FA Cup win, and another blow has struck with the European Championships just four months away.
The Man City manager also revealed Josko Gvardiol will spend a short time out after missing tonight's encounter, stating: "Josko will be out two-three weeks, he has an ankle ligament injury."
That will likely see Nathan Ake continue in a left-back/left centre-back hybrid role that he has occupied in the previous two City games.
Despite all of the injuries coming in a short space of time for Guardiola, he did reveal that Mateo Kovacic may return to face his former club Chelsea at the weekend.
The Croatian midfielder has been missing for both of the club's matches this week with a knock, but could be in line for start given Silva's possible absence.
De Bruyne and Erling Haaland also escaped Copenhagen unscathed, following recent returns from lengthy setbacks of their own.