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Marc-Andre ter Stegen has stood between the posts for two of Germany's last three games - against Armenia and Israel - but FIFA World Cup qualification was already assured in the former, while the latter was a friendly. Flick will be keen to get off on the right foot in what appears to be the strongest Nations League group with England and Hungary also for company, and Bayern Munich and Germany captain Neuer should start. Kevin Trapp - fresh from winning the UEFA Europa League with Eintracht Frankfurt - will be his understudy, with Hoffenheim's Oliver Baumann completing the goalkeeping contingent this time. Further forward, Leon Goretzka was a doubt with an ankle injury, but is available to play, provided he can dislodge Ilkay Gündogan in midfield. Marco Reus is a doubt with flu-like symptoms.
Neuer's opposite number Gianluigi Donnarumma has had to share minutes with Keylor Navas at Paris Saint-Germain this season, but he is the undisputed No.1 for his country. Unlike Germany, Italy won't be at the World Cup in Qatar this winter after losing 1-0 to North Macedonia in March. Roberto Mancini's side remain European champions, though, and Germany will not take them lightly. Former Borussia Dortmund striker Ciro Immobile hasn't been called up due to an ankle injury, so Torino's Andrea Belotti is likely to lead the line at the 38,279 capacity Stadio Renato Dall'Ara. Freiburg's Vincenzo Grifo has not been included this time.
Match stats
Thomas Müller is the most-capped player in Germany's squad with 112. He had three goals and three assists in FIFA World Cup qualifying.
Müller's Bayern teammate Serge Gnabry had the most goal-involvements, though, scoring five and providing two more.
Germany are undefeated in four meetings with Italy, stretching back to their UEFA Euro 2012 semi-final, which the Italians edged 2-1.
Neuer, Müller, Gündogan and Reus are surviving members of that squad from 10 years ago.
Hoffenheim goalkeeper Baumann is the only uncapped player in Flick's 26-man ensemble.
Freiburg's Grifo has six caps and two goals for Italy but has not been called up this time.
Probable teams
Italy: Donnarumma - Di Lorenzo, Bonucci, Chiellini (c), Emerson - Barella, Jorginho, Verratti - Berardi, Belotti, Insigne
Out: -
Doubtful: -
Coach: Roberto Mancini
Germany: Neuer (c) - Klostermann, Kehrer, Rüdiger, Raum - Kimmich, Goretzka - Müller, Havertz, Sane - Werner
Out: -
Doubtful: Reus (flu)
Coach: Hansi Flick
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