The Dutch duo have both been forced to withdraw from the squad for this month's international break due to injury, and have been replaced by Donyell Malen and Joey Veerman.
Veerman is one of six uncapped players in the 25-man squad selected by new head coach Ronald Koeman, who has returned to manage the Oranje following the departure of Louis van Gaal.
After regularly using a three-at-the-back system under Van Gaal, Koeman is expected to deploy a four-man defence, with uncapped Newcastle United defender Sven Botman competing with Matthijs de Ligt and Jurrien Timber for a start at centre-back alongside captain Virgil van Dijk.
Daley Blind is in line to make his 100th international appearance at left-back, although Nathan Ake will be pushing to start following an impressive run of form with Manchester City, while Denzel Dumfries and Jasper Cillessen are expected to begin at right-back and in goal respectively.
In the absence of Frenkie de Jong, Roma's Georginio Wijnaldum could be handed his first international appearance for nearly a year after missing the World Cup through injury, while Marten de Roon and Steven Berghuis are also strong candidates to start.
Luuk de Jong announced his international retirement at the end of last month, so a front three of Memphis Depay, Cody Gakpo and Wout Weghorst could line up in attack, with Malen and Brian Brobbey both options who could make an impact off the substitutes' bench.
Netherlands possible starting lineup: Cillessen; Dumfries, De Ligt, Van Dijk, Ake; Wijnaldum, De Roon, Berghuis; Depay, Weghorst, Gakpo