Nuno, who is standing down from his position at the end of the season, could make a late call on the fitness of Owen Otasowie, who missed out against Everton last time out due to a knock.
The home side will again be without the services of some key players on Sunday, though, as Daniel Podence, Pedro Neto, Jonny and Raul Jimenez remain on the sidelines.
It seems likely that there will be changes from the side that started the 1-0 loss at Everton on Wednesday.
Indeed, Rui Patricio should return between the sticks, while Fernando Marcal, Romain Saiss, Vitinha and Leander Dendoncker could come in for starts against the 20-time English champions.
Nelson Semedo, Joao Moutinho and Ruben Neves should retain their spots in the side, though, while Fabio Silva could again be given the nod alongside Adama Traore in the final third of the field.
Max Kilman and Willy Boly are among those that may drop down to the bench, which could also include Willian Jose, who has struggled to make his mark since arriving on loan from Real Sociedad.
Wolves possible starting lineup: Patricio; Dendoncker, Coady, Saiss; Semedo, Neves, Moutinho, Marcal; Vitinha; Traore, Silva
VOTE IN THE END-OF-SEASON SPORTS MOLE AWARDS!
Have your say in the annual end-of-season Sports Mole Reader Awards!